Genomic diversity of EPEC associated with clinical presentations of differing severity.
Genomic diversity of EPEC associated with clinical presentations of differing severity.
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DOI：
10.1038/nmicrobiol.2015.14
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发表时间：
2016-01-18
影响因子：
28.3
通讯作者：
Nataro, James P.
中科院分区：
文献类型：
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作者：
Hazen, Tracy H.;Donnenberg, Michael S.;Panchalingam, Sandra;Antonio, Martin;Hossain, Anowar;Mandomando, Inacio;Ochieng, John Benjamin;Ramamurthy, Thandavarayan;Tamboura, Boubou;Qureshi, Shahida;Quadri, Farheen;Zaidi, Anita;Kotloff, Karen L.;Levine, Myron M.;Barry, Eileen M.;Kaper, James B.;Rasko, David A.;Nataro, James P.
肠致病性大肠杆菌（EPEC）是一种产酶大肠杆菌。大肠杆菌，是发展中国家幼儿胃肠道疾病的一个重要原因。典型的EPEC通过存在由毒力质粒编码的形成菌毛来鉴定，这与疾病的严重程度增加有关，而非典型的EPEC缺乏这一特征。使用来自全球肠道多中心研究中招募的儿童肠道疾病致死性（LI）、非致死性症状性（NSI）或无症状性（AI）病例的70例EPEC的比较基因组学，研究从具有不同临床结局的个体中获得的EPEC分离株的基因组差异。对不同临床结局的分离株基因组进行比较，发现有症状和致死性结局的EPEC分离株中的基因比无症状结局的EPEC分离株中的基因明显更普遍。这些EPEC分离株表现出以前未被重视的基因组多样性和毒力因子的组合。这些比较结果突出了病原体的多样性，以及EPEC毒力因子库的复杂性。
Enteropathogenic Escherichia coli (EPEC) are diarrhoeagenic E. coli, and are a significant cause of gastrointestinal illness among young children in developing countries. Typical EPEC are identified by the presence of the bundle-forming pilus encoded by a virulence plasmid, which has been linked to an increased severity of illness, while atypical EPEC lack this feature. Comparative genomics of 70 total EPEC from lethal (LI), non-lethal symptomatic (NSI) or asymptomatic (AI) cases of diarrhoeal illness in children enrolled in the Global Enteric Multicenter Study was used to investigate the genomic differences in EPEC isolates obtained from individuals with various clinical outcomes. A comparison of the genomes of isolates from different clinical outcomes identified genes that were significantly more prevalent in EPEC isolates of symptomatic and lethal outcomes than in EPEC isolates of asymptomatic outcomes. These EPEC isolates exhibited previously unappreciated phylogenomic diversity and combinations of virulence factors. These comparative results highlight the diversity of the pathogen, as well as the complexity of the EPEC virulence factor repertoire.
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影响因子：
--
作者：
Galens K;Orvis J;Daugherty S;Creasy HH;Angiuoli S;White O;Wortman J;Mahurkar A;Giglio MG
通讯作者：
Giglio MG
影响因子：
3.1
作者：
Perna, NT;Mayhew, GF;Blattner, FR
通讯作者：
Blattner, FR
影响因子：
3.2
作者：
Lacher, David W.;Steinsland, Hans;Whittam, Thomas S.
通讯作者：
Whittam, Thomas S.
影响因子：
3.2
作者：
Iguchi, Atsushi;Thomson, Nicholas R.;Frankel, Gad
通讯作者：
Frankel, Gad
影响因子：
168.9
作者：
Kotloff, Karen L.;Nataro, James P.;Levine, Myron M.
通讯作者：
Levine, Myron M.