Dynamic Hysteresis Measurement of Magnetic Nanoparticle Suspensions in Parallel and Perpendicular DC Magnetic Fields
Dynamic Hysteresis Measurement of Magnetic Nanoparticle Suspensions in Parallel and Perpendicular DC Magnetic Fields
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DOI：
10.1109/tmag.2020.3021428
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发表时间：
2021-02-01
影响因子：
2.1
通讯作者：
Yanagihara, Hideto
中科院分区：
文献类型：
--
作者：
Onodera, Reisho;Kita, Eiji;Yanagihara, Hideto
研究了直流偏置磁场对动态磁化过程的影响，以评估磁性纳米颗粒（NP）悬浮液对磁热疗的加热能力增强以及联合治疗的可行性。在磁热疗期间，直流磁场可与磁共振成像（MRI）和磁性药物输送技术结合使用。测量交变磁场（AMF）下的动态磁化曲线是了解热疗加热机制的另一种技术。在频率为50 - 200 kHz的AMF下测量动态磁化曲线，最大振幅（mu H-0(0)）为70 mT。平行和/或垂直于AMF施加高达50 mT的去偏磁场（mu H-0(dc)）。测量两种NP悬液；一种是市售的超顺磁（SPM）悬浮液Resovist (R) (Ferucarbonate)，另一种是SCF-3，它由球形铁磁Co取代Fe3O4 NPs组成，干燥后表现出铁磁特性。当直流磁场（dc- mf）垂直于AMF施加时，环路面积比并联dc- mf施加时减少得更慢。通过与铁磁NP悬浮液的比较，得出结论：外部直流- mf作用下，磁悬浮液的弛豫行为是导致环路面积减小的原因。
The effect of a dc bias magnetic field on the dynamic magnetization process was examined to evaluate the enhancement in the heating ability of magnetic nanoparticle (NP) suspensions for magnetic hyperthermia and the passibility of combination therapies. A dc magnetic field may be used with a combination of magnetic resonance imaging (MRI) and magnetic drug delivery techniques during magnetic hyperthermia. Measuring dynamic magnetization curves under an alternating magnetic field (AMF) is another technique to understand the heating mechanism in hyperthermia. The dynamic magnetization curves were measured under an AMF at frequencies between 50 and 200 kHz with a maximum amplitude (mu H-0(0)) of 70 mT. A de bias magnetic field (mu H-0(dc)) of up to 50 mT was applied parallel and/or perpendicular to the AMF. Two NP suspensions were measured; one is a commercially available superparamagnetic (SPM) suspension, Resovist (R) (Ferucarbonate), and the other is SCF-3, which is composed of spherical ferromagnetic Co substituted Fe3O4 NPs and shows ferromagnetic characteristics in its dried form. When a dc magnetic field (dc-MF) was applied perpendicular to the AMF, the loop areas decreased more gradually than when a parallel dc-MF was applied. It is concluded that the relaxation behaviors of magnetic suspensions are responsible to the reduction in loop areas by an external dc-MF based on a comparison with the ferromagnetic NP suspension.