Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.
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合成 N3,5-环-4-(β-D-呋喃核糖基)-vic-三唑并[4,5-b]吡啶-5-酮及其 3-脱氧糖类似物作为潜在的抗丙型肝炎病毒剂。
DOI：
10.1081/ncn-200059314
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Watanabe,KyoichiA
中科院分区：
文献类型：
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作者：
Wang,Peiyuan;Hollecker,Laurent;Pankiewicz,KrzysztofW;Patterson,StevenE;Whitaker,Tony;McBrayer,TamaraR;Tharnish,PhillipM;Stuyver,LievenJ;Schinazi,RaymondF;Otto,MichaelJ;Watanabe,KyoichiA
We recently discovered a novel compound, identified as N3,5′-cyclo-4-(β-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, with anti-hepatitis C virus (HCV) activity in vitro. The structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine. It showed anti-HCV activity with EC50=19.7 μM in replicon cells. Its 3′-deoxy sugar analogue was also synthesized, but was inactive against HCV in vitro.
