Effect of dehydration on thirst and drinking during immersion in men.
Effect of dehydration on thirst and drinking during immersion in men.
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脱水对男性浸泡期间口渴和饮水的影响。
DOI：
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发表时间：
1992
影响因子：
3.3
通讯作者：
J. Greenleaf
中科院分区：
文献类型：
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作者：
S. Sagawa;K. Miki;F. Tajima;H. Tanaka;J. K. Choi;L. Keil;K. Shiraki;J. Greenleaf
在8名男性（19-25岁）中研究了在浸水过程中减少自愿饮水量的机制，这些男性在34.5 ℃下或在28 ℃下的空气中坐着3小时，同时在正常水化（分别为Eu-H2O和Eu-air）和欠水化（Hypo-H2O和Hypo-air）时浸入颈部，体重减轻3.6%。在低空气和低H2O试验期开始时，口渴感觉（口渴程度、口干和味觉、饮水欲望和胃胀满）相似。初始饮用自来水（15 ℃）为216 +/- 30 ml/7 min（P <0.05），使用Hypo-air，降至108 +/- 28 ml/7 min（P <0.05），使用Hypo-H2O，此后为10-50 ml/10-30 min。在Eu-air中的摄入量小于10 ml/10-30 min，在Eu-H2O中没有饮水。在浸泡的前10分钟内，与低空气研究结果相比，低H2O实验中饮酒量的显著减少与血浆Na+、血浆渗透压、心率和平均动脉压不变有关;不同的反应是心输出量、血浆容量和心钠素增加，血浆肾素活性和精氨酸加压素降低。因此，细胞外途径，而不是渗透途径，似乎是浸泡诱导抑制饮水的主要机制。
The mechanism for reduced voluntary water intake during water immersion was studied in eight men (19-25 yr of age) immersed to the neck while sitting for 3 h at 34.5 degrees C or in air at 28 degrees C when euhydrated (Eu-H2O and Eu-air, respectively) and hypohydrated (Hypo-H2O and Hypo-air) by 3.6% body weight loss. Thirst sensations (degree of thirst, mouth dryness and taste, drinking desirability, and stomach fullness) were similar at the beginning of Hypo-air and Hypo-H2O test periods. Initial drinking of tap water (15 degrees C) was 216 +/- 30 ml/7 min (P less than 0.05) with Hypo-air, decreased to 108 +/- 28 ml/7 min (P less than 0.05) with Hypo-H2O, and was 10-50 ml/10-30 min thereafter. Intake was less than 10 ml/10-30 min in Eu-air, and there was no drinking in Eu-H2O. Within the first 10 min of immersion, compared with Hypo-air findings, the significant reduction in drinking in the Hypo-H2O experiment was associated with unchanged plasma Na+, plasma osmolality, heart rates, and mean arterial pressures; the different responses were increased cardiac output, plasma volume, and atrial natriuretic peptides and decreased plasma renin activity and arginine vasopressin. Thus the extracellular pathway, as opposed to the osmotic pathway, appears to be the major mechanism for immersion-induced suppression of drinking.