GeneCards™ 2002:: towards a complete, object-oriented, human gene compendium
GeneCards™ 2002:: towards a complete, object-oriented, human gene compendium
复制标题
DOI：
10.1093/bioinformatics/18.11.1542
复制
发表时间：
2002-11-01
期刊：
影响因子：
5.8
通讯作者：
Lancet, D
中科院分区：
文献类型：
--
作者：
Safran, M;Solomon, I;Lancet, D
动机：在后基因组时代，基因的功能分析需要复杂的跨学科武器库。结果：GeneCards(Rebhan等人，1998)取得了创新的进展：(A)定期更新和增强了新的基因，这些新基因丰富了序列、基因组位置、cDNA组装、正交学、医学信息、3D蛋白质结构、基因表达和集中的SNP摘要；(B)使用面向对象的Perl重构了软件，迁移到模式驱动的XML，以及(C)试点研究，引入了为新的和预测的基因制作卡片的方法。
Motivation: In the post-genomic era, functional analysis of genes requires a sophisticated interdisciplinary arsenal. Comprehensive resources are challenged to provide consistently improving, state-of-the-art tools.Results: GeneCards (Rebhan et al., 1998) has made innovative strides: (a) regular updates and enhancements incorporating new genes enriched with sequences, genomic locations, cDNA assemblies, orthologies, medical information, 3D protein structures, gene expression, and focused SNP summaries; (b) restructured software using object-oriented Perl, migration to schema-driven XML, and (c) pilot studies, introducing methods to produce cards for novel and predicted genes.