What cause of mortality can we predict by cholesterol screening in the Japanese general population?
What cause of mortality can we predict by cholesterol screening in the Japanese general population?
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DOI：
10.1046/j.1365-2796.2003.01080.x
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发表时间：
2003-02-01
影响因子：
11.1
通讯作者：
Ueshima, H
中科院分区：
文献类型：
--
作者：
Okamura, T;Kadowaki, T;Ueshima, H
Objective.在冠状动脉死亡率明显较低的人群中，如日本，胆固醇筛查的益处可能与西方人群不同。我们试图评估胆固醇筛查在日本的重要性。病因特异性死亡率的13.2年队列研究在日本全国随机选择300个地区进行1980年全国循环系统疾病调查。共收集9216名30岁及以上的社区居民，进行标准化血清胆固醇测量，既往无心血管疾病史。死亡1206例，其中心血管疾病死亡462例，冠心病死亡79例。高胆固醇血症（>6.21 mmol L-1）与冠状动脉死亡率（相对危险度; 2.93，95%置信区间; 1.52-5.63）呈显著正相关，但与卒中无关。虽然低胆固醇血症（
Objective. In a population with a markedly lower coronary mortality such as in Japan, the benefit of cholesterol screening may be different from Western populations. We attempted to assess the importance of cholesterol screening in Japan.Design. A 13.2-year cohort study for cause-specific mortality.Setting. Three hundred randomly selected districts throughout Japan in which the National Survey on Circulatory Disorders 1980 was performed.Subjects. A total of 9216 community dwelling persons aged 30 years and over, with standardized serum cholesterol measurement and without a past history of cardiovascular disease.Results. There were 1206 deaths, which included 462 deaths due to cardiovascular disease with 79 coronary heart diseases. Hypercholesterolemia (>6.21 mmol L-1 ) showed a significant positive relation to coronary mortality (relative risk; 2.93, 95% confidence interval; 1.52-5.63) but not to stroke. Although hypocholesterolemia (