Use of multisystemic therapy to improve antiretroviral adherence and health outcomes in HIV-infected pediatric patients: Evaluation of a pilot program
Use of multisystemic therapy to improve antiretroviral adherence and health outcomes in HIV-infected pediatric patients: Evaluation of a pilot program
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DOI：
10.1089/apc.2006.20.112
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发表时间：
2006-02-01
影响因子：
4.9
通讯作者：
Secord, E
中科院分区：
文献类型：
--
作者：
Ellis, DA;Naar-King, S;Secord, E
本研究的目的是评估一项临床计划，该计划使用多系统治疗（MST）来改善围产期获得性HIV儿童的方案依从性和健康结局，这些儿童在没有病毒耐药性的情况下表现出高病毒载量。MST是一种密集的，以家庭为基础的家庭治疗，以前用于治疗严重的反社会行为。这项研究的目的是评估MST计划的可行性及其对改善接受治疗的儿童健康状况的有效性。本研究通过回顾性病历审查进行。90%的儿童和家庭接受了转诊，95%的人接受了全剂量的治疗，这表明该计划具有很高的可行性。19名儿童参加了该方案。在治疗过程中，护理人员对艾滋病毒的一般知识有了显著提高。尽管患者报告的依从性没有变化，但发现从转诊到MST治疗结束，病毒载量显著下降，平均变化反映了大于1 log（10）的下降。大多数儿童在治疗终止后的3个月内保持这些改善。结果表明，MST有望作为一种干预措施，改善儿童艾滋病毒感染者的健康状况。
The purpose of the current study was to evaluate a clinical program that used multisystemic therapy (MST) to improve regimen adherence and health outcomes among children with perinatally acquired HIV who exhibited high viral loads in the absence of viral resistance. MST is an intensive, home-based family therapy previously used for the treatment of serious antisocial behavior. Goals of the study were to assess the feasibility of the MST program and its effectiveness for improving health outcomes among children who were treated. The study was conducted by retrospective chart review. Ninety percent of children and families referred to the program accepted the referral and 95% received a full dose of treatment, suggesting high program feasibility. Nineteen children participated in the program. General HIV knowledge on the part of caregivers improved significantly over the course of treatment. Although caregiver-reported adherence did not change, viral loads were found to significantly decrease from referral to the end of MST treatment, with the mean change reflecting a greater than 1 log(10) decrease. The majority of children maintained these improvements during the 3 months after treatment termination. Results suggest that MST holds promise as an intervention for improving health outcomes among pediatric patients with HIV.