Pulmonary tissue volume in dogs during pulmonary edema.
Pulmonary tissue volume in dogs during pulmonary edema.
复制标题
肺水肿期间狗的肺组织体积。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
B. Schreiner
中科院分区：
文献类型：
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作者：
B. Peterson;M. Petrini;R. Hyde;B. Schreiner
在麻醉犬中，通过分析在30秒重复呼吸动作期间二甲醚（DME）、乙炔（C2 H2）和六氟化硫的呼气末浓度来测量肺组织体积（Vt）和肺毛细血管血流量（Qc）。将Vt与对照犬和血流动力学和非血流动力学（四氧嘧啶）肺水肿犬的死后肺重量进行比较。将Qc与通过染料稀释测量的心输出量进行比较。肺泡容积（VA）在1-2升范围内增加100 ml导致Vt增加9 +/- 3 ml。在VA为1.9 L时测量的Vt为20只对照犬和6只中度水肿犬（肺重量<预测值的250%）死后肺重量的114 ± 18%。在11只水肿更严重的犬中，Vt仅为肺重量的53 ± 14%。DME和C_2H_2的Vt平均值较小，但DME的重复性较好（DME和8%C_2H_2的变异系数为5%）。在再呼吸操作期间，Qc测量到96 +/ 15%的心输出量，但该操作导致心输出量下降4-40%。这些数据表明，在肺水肿犬中，通过再呼吸DME确定的Vt在肺重量的86%至135%之间，直到肺重量大于预测值的250%。
Pulmonary tissue volume (Vt) and pulmonary capillary blood flow (Qc) were measured in anesthetized dogs by analyzing end-expiratory concentrations of dimethyl ether (DME), acetylene (C2H2), and sulfur hexafluoride during a 30-s rebreathing maneuver. Vt was compared to the postmortem lung weight of control dogs and dogs with hemodynamic and nonhemodynamic (alloxan) pulmonary edema. Qc was compared to the cardiac output measured by dye dilution. A 100-ml increase in alveolar volume (VA) in the range of 1-2 liters resulted in a 9 +/- 3 ml increase in Vt. Vt measured at a VA of 1.9 liters measures 114 +/- 18% of the postmortem lung weight in 20 control dogs and in 6 dogs with moderate edema (lung weight < 250% of predicted). Vt measured only 53 +/- 14% of the lung weight in 11 dogs with more severe edema. DME and C2H2 gave the smae mean values of Vt, but the reproducibility of a series of 3-7 measurements was greater with DME (coefficient of variation was 5% with DME and 8% C2H2). Qc measured 96 +/ 15% of the cardiac output during the rebreathing maneuver, but the maneuver caused a 4-40% fall in the cardiac output. These data show that Vt determined by rebreathing DME is between 86% and 135% of the lung weight in dogs with pulmonary edema until the lung weight is greater than 250% of the predicted value.