Mechanisms of allergen-specific immunotherapy.
Mechanisms of allergen-specific immunotherapy.
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DOI：
10.1186/2045-7022-2-2
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发表时间：
2012-01-05
影响因子：
4.4
通讯作者：
Akdis CA
中科院分区：
文献类型：
--
作者：
Fujita H;Soyka MB;Akdis M;Akdis CA
过敏原特异性免疫治疗（allergen-SIT）是一种潜在的治疗过敏性疾病的方法。它作为脱敏疗法已经使用了近100年。诱导外周血T细胞耐受和促进调节性T细胞的形成是变应原-SIT的关键机制。FOXP 3 + CD 4 + CD 25+调节性T（Treg）细胞和产生IL-10和TGF-β的诱导型1型Treg（Tr 1）细胞均可预防过敏性疾病的发生，并通过多种机制在成功的变应原-SIT和健康的免疫应答中发挥作用。抑制不同的促炎细胞（如嗜酸性粒细胞、肥大细胞和嗜碱性粒细胞）的机制以及过敏原耐受性的发展也直接或间接涉及Treg细胞。此外，非炎性抗体特别是IgG 4的形成由IL-10诱导。了解这些分子基础对于理解过敏性疾病中免疫应答的调节及其可能的治疗靶点至关重要。
Allergen-specific immunotherapy (allergen-SIT) is a potentially curative treatment approach in allergic diseases. It has been used for almost 100 years as a desensitizing therapy. The induction of peripheral T cell tolerance and promotion of the formation of regulatory T-cells are key mechanisms in allergen-SIT. Both FOXP3+CD4+CD25+ regulatory T (Treg) cells and inducible IL-10- and TGF-β-producing type 1 Treg (Tr1) cells may prevent the development of allergic diseases and play a role in successful allergen-SIT and healthy immune response via several mechanisms. The mechanisms of suppression of different pro-inflammatory cells, such as eosinophils, mast cells and basophils and the development of allergen tolerance also directly or indirectly involves Treg cells. Furthermore, the formation of non-inflammatory antibodies particularly IgG4 is induced by IL-10. Knowledge of these molecular basis is crucial in the understanding the regulation of immune responses and their possible therapeutic targets in allergic diseases.