Novel Temperature/Reduction Dual-Stimulus Responsive Triblock Copolymer [P(MEO(2)MA-co- OEGMA)-b-PLLA-SS-PLLA-b-P(MEO(2)MA-co-OEGMA)] via a Combination of ROP and ATRP: Synthesis, Characterization and Application of Self-Assembled Micelles.
Novel Temperature/Reduction Dual-Stimulus Responsive Triblock Copolymer [P(MEO(2)MA-co- OEGMA)-b-PLLA-SS-PLLA-b-P(MEO(2)MA-co-OEGMA)] via a Combination of ROP and ATRP: Synthesis, Characterization and Application of Self-Assembled Micelles.
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DOI：
10.3390/polym12112482
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发表时间：
2020-10-26
期刊：
影响因子：
5
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Song F;Wang Z;Gao W;Fu Y;Wu Q;Liu S
新型温度/还原双重刺激响应性三嵌段共聚物聚[2-甲基丙烯酸（2-甲氧基乙氧基）乙酯-共聚-低聚物甲基丙烯酸乙二醇酯]-B-（L-聚乳酸）-SS-b-（L-聚乳酸）-b-聚[2-甲基丙烯酸（2-甲氧基乙氧基）乙酯-共聚-低聚物甲基丙烯酸乙二醇酯] [P（MEO2MA-co-OEGMA）-b-PLLA-SS-PLLA-b-P（MEO 2 MA-co-OEGMA）]（SPMO），通过L-丙交酯和2，2 ′-二硫代二乙醇（SS-DOH）的开环聚合（ROP），采用原子转移自由基聚合（ATRP）技术，将MEO 2 MA和OEGMA单体进行无规共聚。用核磁共振氢谱（1H NMR）和傅里叶变换红外光谱（FTIR）表征了共聚物的结构和组成。用尺寸排阻色谱法（SEC）测定了共聚物的相对分子质量，结果表明共聚物具有较窄的相对分子质量分布系数（Mw M ≤ 1.50）。通过目视观察和紫外-可见光谱测试了共聚物的水溶性和透光率，证明SPMO具有良好的亲水性和合适的低临界溶解温度（LCST）。采用表面张力法和荧光探针技术测定了新型聚合物胶束的临界胶束浓度（CMC）。用动态光散射（DLS）和透射电子显微镜（TEM）对聚合物胶束的粒径和形貌进行了表征。通过小瓶翻转实验研究了新型共聚物的溶胶-凝胶转变行为。最后，以疏水性抗癌药物阿霉素（DOX）为例，研究了新型载药胶束的体外释药行为。结果表明，这种新型聚合物胶束有望成为一种良好的药物载体。此外，它们表现出对小分子还原剂二硫苏糖醇（DTT）的还原响应性和对温度变化的温度响应性。
Novel temperature/reduction dual stimulus-responsive triblock copolymers, poly [2-(2-methoxyethoxy) ethyl methacrylate-co-oligo (ethylene glycol) methacrylate]-b-(L-polylactic acid)-SS-b-(L-polylactic acid)-b-poly[2-(2-methoxyethoxy) ethyl methacrylate-co-oligo(ethylene glycol)methacrylate] [P(MEO2MA-co-OEGMA)-b-PLLA-SS-PLLA-b-P(MEO2MA-co-OEGMA)] (SPMO), were synthesized by ring opening polymerization (ROP) of L-lactide and 2,2’-dithio diethanol (SS-DOH), and random copolymerization of MEO2MA and OEGMA monomers via atom transfer radical polymerization (ATRP) technology. The chemical structures and compositions of the novel copolymers were demonstrated by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy (FTIR). The molecular weights of the novel copolymers were measured by size exclusive chromatography (SEC) and proved to have a relatively narrow molecular weight distribution coefficient (ÐM ≤ 1.50). The water solubility and transmittance of the novel copolymers were tested via visual observation and UV–Vis spectroscopy, which proved the SPMO had a good hydrophilicity and suitable low critical solution temperature (LCST). The critical micelle concentration (CMC) of the novel polymeric micelles were determined using surface tension method and fluorescent probe technology. The particle size and morphology of the novel polymeric micelles were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The sol–gel transition behavior of the novel copolymers was studied via vial flip experiments. Finally, the hydrophobic anticancer drug doxorubicin (DOX) was used to study the in vitro release behavior of the novel drug-loaded micelles. The results show that the novel polymeric micelles are expected to become a favorable drug carrier. In addition, they exhibit reductive responsiveness to the small molecule reducing agent dithiothreitol (DTT) and temperature responsiveness with temperature changes.
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影响因子：
5.5
作者：
Lutz, JF;Hoth, A
通讯作者：
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作者：
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