The genesis of human hematopoietic stem cells.
The genesis of human hematopoietic stem cells.
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DOI：
10.1182/blood.2022017934
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发表时间：
2023-08-10
期刊：
影响因子：
20.3
通讯作者：
Mikkola, Hanna K. A.
中科院分区：
文献类型：
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作者：
Calvanese, Vincenzo;Mikkola, Hanna K. A.
发育性造血包括多个部分重叠的造血波，这些造血波产生胚胎发育所需的分化血细胞，同时为出生后的生活建立未分化的造血干细胞（hsc）库。这种活跃的造血功能通过多种胚胎外组织和胚胎内组织迁移的多层设计使得很难确定造血干细胞与非自我更新祖细胞的生成路线图，特别是在人类中。最近的单细胞研究有助于在功能测定不适合与祖细胞区分的阶段识别罕见的人类造血干细胞。这种方法使得人类造血干细胞的起源可以追溯到主动脉-性腺-中肾区独特类型的动脉内皮，并记录了造血干细胞在妊娠期迁移和成熟的新基准。这些研究为造血干细胞生成的复杂过程提供了新的见解，并为在体外复制多能干细胞通过不同的中胚层和内皮中间体到造血干细胞的生理发育过程提供了工具。由副主编John Crispino编辑，本综述系列关注造血干细胞（HSC）生物学，超越小鼠HSC生物学的工作，强调人类HSC的发育和表征。该领域的专家作者涵盖了从个体发生到衰老和白血病转化的主题。我们希望这些博学多才的文章能够促进研究，开发出新的策略来逆转衰老的影响，防止恶性转化，并增强多能干细胞在体外的造血干细胞生产。
Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic waves that generate the differentiated blood cells required for embryonic development while establishing a pool of undifferentiated hematopoietic stem cells (HSCs) for postnatal life. This multilayered design in which active hematopoiesis migrates through diverse extra and intraembryonic tissues has made it difficult to define a roadmap for generating HSCs vs non–self-renewing progenitors, especially in humans. Recent single-cell studies have helped in identifying the rare human HSCs at stages when functional assays are unsuitable for distinguishing them from progenitors. This approach has made it possible to track the origin of human HSCs to the unique type of arterial endothelium in the aorta-gonad-mesonephros region and document novel benchmarks for HSC migration and maturation in the conceptus. These studies have delivered new insights into the intricate process of HSC generation and provided tools to inform the in vitro efforts to replicate the physiological developmental journey from pluripotent stem cells via distinct mesodermal and endothelial intermediates to HSCs. Edited by Associate Editor John Crispino, this Review Series focuses on hematopoietic stem cell (HSC) biology, going beyond the work in murine HSC biology and emphasizing development and characterization of human HSCs. Expert authors in the field cover topics ranging from ontogeny to aging and leukemia transformation. We hope that these erudite articles will stimulate research that develops novel strategies to reverse the effects of aging, prevent malignant transformation, and enhance in vitro production of HSCs from pluripotent stem cells.
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影响因子：
64.8
作者：
Chen, Michael J.;Yokomizo, Tomomasa;Zeigler, Brandon M.;Dzierzak, Elaine;Speck, Nancy A.
通讯作者：
Speck, Nancy A.
影响因子：
7.7
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Bartelmez, GW
影响因子：
9.8
作者：
Canu G;Ruhrberg C
通讯作者：
Ruhrberg C
影响因子：
21.3
作者：
通讯作者：
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