Measurement of damage in 210 Mexican patients with systemic lupus erythematosus: relationship with disease duration
Measurement of damage in 210 Mexican patients with systemic lupus erythematosus: relationship with disease duration
复制标题
DOI：
10.1191/096120398678919831
复制
发表时间：
1998-01-01
期刊：
影响因子：
2.6
通讯作者：
Fraga, A
中科院分区：
文献类型：
--
作者：
Zonana-Nacach, A;Camargo-Coronel, A;Fraga, A
系统性狼疮国际合作诊所/美国流变学学会（SLICC/ACR）损伤指数是一种经过验证的工具，专门用于确定SLE的损伤;该工具主要适用于白人和非裔美国人SLE患者。本研究的目的是使用SLICC/ACR损伤指数评估墨西哥SLE患者的损伤。SLICC/ACR损伤指数应用于210例病程不同的连续SLE患者。通过审查医院临床记录、访谈和体检来评估SLICC/ACR损伤指数。117例（55.5%）患者有一定程度的损伤。随着病程的延长，出现损伤的患者比例明显增加（1-60个月为33%，61-120个月为66%，≥ 121个月为70%，P < 0.001）。受累的主要器官系统为肌肉骨骼（骨坏死）、神经精神（神经病、癫痫）、性腺（40岁以前闭经）、眼（白内障）、肾（肾小球滤过
The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index is a validated instrument specifically designed to ascertain damage in SLE; this instrument has been applied mainly to Caucasians and African-American SLE patients. The objective of this study was to assess damage using the SLICC/ACR Damage Index in Mexican SLE patients. The SLICC/ACR Damage Index was applied to 210 consecutive SLE patients with disease of variable duration. The SLICC/ACR Damage Index was assessed by review of hospital clinical records, interview and physical examination. One hundred and seventeen (55.5%) patients had some damage. The proportion of patients with damage increased significantly with disease duration (33% at 1-60 months, 66% at 61-120 months and 70% at greater than or equal to 121 months, P < 0.001). The main organ systems involved were musculoskeletal (osteonecrosis), neuropsychiatric (neuropathy, seizures), gonadal (amenorrhea prior to age 40 years), ocular (cataracts), renal (glomerular filtration