A randomised controlled trial to compare a range of commercial or primary care led weight reduction programmes with a minimal intervention control for weight loss in obesity: the Lighten Up trial
A randomised controlled trial to compare a range of commercial or primary care led weight reduction programmes with a minimal intervention control for weight loss in obesity: the Lighten Up trial
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DOI：
10.1186/1471-2458-10-439
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发表时间：
2010-07-27
影响因子：
4.5
通讯作者：
Aveyard, Paul
中科院分区：
文献类型：
--
作者：
Jolly, Kate;Daley, Amanda;Aveyard, Paul
背景：发达国家正面临着肥胖及其相关慢性疾病患病率的大幅上升。在英国，初级保健信托基金负责解决他们所服务的人群中的这一问题，但没有关于提供服务的最有效方式的证据。本研究的目的是确定一系列减肥计划对肥胖患者在初级保健中的有效性，并确定响应免费体重管理计划邀请的患者的特征。方法/设计：Litten Up是一项随机对照试验，比较了12-一个为期一周的商业和国民保健服务减肥计划与对照组谁提供了12个优惠券，使免费进入当地的休闲中心。这些减肥方案是：（一）减肥观察者，（二）减肥世界，（三）迷迭香康利，（四）以小组为基础的饮食学主导方案（减肥），（五）全科一对一咨询，（六）药房主导的一对一咨询，（七）选择6个方案中的任何一个。肥胖或超重伴共病的人可以通过他们的全科医生的来信邀请参加。样本量为740人。主要结局是项目结束时（3个月）的体重减轻。次要结果是体重减轻在一年，自我报告的体力活动在3个月和12个月的后续行动和百分比体重减轻在3个月和一year.Discussion：这项试验将提供证据的有效性的一系列不同的体重管理计划在初级保健人群。
Background: Developed countries are facing a huge rise in the prevalence of obesity and its associated chronic medical problems. In the UK Primary Care Trusts are charged with addressing this in the populations they serve, but evidence about the most effective ways of delivering services is not available. The aim of this study is to determine the effectiveness of a range of weight loss programmes for obese patients in primary care and to determine the characteristics of patients who respond to an invitation to a free weight management programme.Methods/Design: Lighten Up is a randomised controlled trial comparing a range of 12-week commercial and NHS weight reduction programmes with a comparator group who are provided with 12 vouchers enabling free entrance to a local leisure centre. The weight reduction programmes are: (i) Weight Watchers, (ii) Slimming World, (iii) Rosemary Conley, (iv) a group-based dietetics-led programme (Size Down), (v) general practice one-to-one counselling, (vi) pharmacy-led one-to-one counselling, (vii) choice of any of the 6 programmes. People with obesity or overweight with a co-morbid disorder are invited to take part by a letter from their general practitioner. The sample size is 740 participants. The primary outcome is weight loss at programme-end (3 months). Secondary outcomes are weight-loss at one year, self-reported physical activity at 3 and 12 months follow-up and percentage weight-loss at 3 months and one year.Discussion: This trial will provide evidence about the effectiveness of a range of different weight management programmes in a primary care population.