Human papillomavirus: E6 and E7 oncogenes
Human papillomavirus: E6 and E7 oncogenes
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DOI：
10.1016/j.biocel.2007.07.004
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
Bogers, Johannes
中科院分区：
文献类型：
--
作者：
Boulet, Gaele;Horvath, Caroline;Bogers, Johannes
近30年前，人们认识到人乳头瘤病毒与癌症之间的因果关系，导致该领域知识的迅速扩展，从而描述了hpv诱导癌变的主要介质，病毒蛋白E6和ET。这些癌蛋白在结合宿主细胞蛋白方面表现出显著的多效性，肿瘤抑制基因p53和pRb是它们的主要靶点。这些相互作用诱导受感染细胞的增殖、永生化和恶性转化。HPV和宫颈癌之间的联系导致了分子方法的发展，通常基于E6和E7的检测，用于筛查和诊断。治疗性疫苗和基因治疗主要针对E6和ET，尽管预防性疫苗是可用的，但进一步了解病毒生命周期和HPV诱导肿瘤发生的机制对于面对HPV和癌症领域的许多挑战是必要的。(C) 2007 Elsevier Ltd.版权所有。
The recognition of a causal relationship between human papillomaviruses and cancer almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the description of the main mediators of HPV-induced carcinogenesis, the viral proteins E6 and ET These oncoproteins show a remarkable pleiotropism in binding host-cell proteins, with the tumour suppressor genes p53 and pRb as their major targets. These interactions induce proliferation, immortalization and malignant transformation of infected cells.The link between HPV and cervical cancer led to the development of molecular methods, often based on the detection of E6 and E7, for screening and diagnosis. Therapeutic vaccines and gene therapy are primarily directed at E6 and ET Although prophylactic vaccines are available, further understanding of the viral life cycle and the mechanisms underlying HPV-induced oncogenesis is necessary to face the many challenges in the field of HPV and cancer. (C) 2007 Elsevier Ltd. All rights reserved.