The role of the left anterior temporal lobe in the semantic processing of famous faces
The role of the left anterior temporal lobe in the semantic processing of famous faces
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DOI：
10.1016/j.neuroimage.2010.06.045
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发表时间：
2010-11-01
期刊：
影响因子：
5.7
通讯作者：
Joubert, Sven
中科院分区：
文献类型：
--
作者：
Brambati, Simona Maria;Benoit, Sophie;Joubert, Sven
对健康受试者的神经影像学研究已经报道了双侧前颞叶（ATL）参与识别已知的人，虽然右ATL在已知的人的语义处理中的作用是公认的，但左ATL是否参与名字提取或语义信息的获取仍然是一个争论的问题。在本fMRI研究中，我们调制的知名面孔刺激的语义分类任务的特异性水平，以映射的特定语义处理控制自动名称访问的大脑区域。具体而言，参与者（n = 12，平均年龄= 230 ± 1.7岁，女/男= 8/4）被要求确定刺激照片是否与职业类别的标签相匹配。对比这两种情况下控制的激活，由于自动访问的名人的名字结果表明，1）对名人面孔刺激的语义分类任务在一般水平和特定水平上激活了右ATL，2）在控制自动名字提取引起的激活时，左ATL在特定分类任务中显示出更高的激活，3）语义加工的特异性增加了从右侧梭状回到左侧ATL的连接强度，致力于面孔的视觉加工，这些发现支持了左前颞叶在处理个人特定的语义信息中的重要作用的想法。(C)2010爱思唯尔公司版权所有
Neuroimaging studies on healthy subjects have reported the involvement of the bilateral anterior temporal lobes (ATL) in recognizing known people While the role of the right ATL in the semantic processing of known people is accepted, it is still matter of debate whether left ATL is implicated in the name retrieval or in the access to semantic information. In the present fMRI study, we modulated the level of specificity of the semantic categorization task of famous face stimuli in order to map the brain regions involved in the specific semantic processing controlling for automatic name access. Specifically, participants (n = 12, mean age = 23 0 +/- 1.7 years, F/M = 8/4) were asked to determine whether the stimulus photograph matched with the label of the profession category Since the same set of stimuli was used for both specific and general conditions, contrasting these two conditions controlled for the activation due to the automatic access to the name of famous persons Results showed that 1) the right ATL was activated by a semantic categorization task of famous face stimuli at both general and specific level, 2) while controlling for the activation due to the automatic name retrieval, the left ATL showed increased activation during the specific categorization task, 3) the specificity of the semantic processing increased strength of connections towards the left ATL from the right lateral fusiform gyrus, devoted to the visual processing of faces, and from the right ATL These findings support the idea of a crucial role of the left anterior temporal lobe in the processing of person-specific semantic information. (C) 2010 Elsevier Inc All rights reserved