Transgenic mouse models of hormonal mammary carcinogenesis: advantages and limitations.
Transgenic mouse models of hormonal mammary carcinogenesis: advantages and limitations.
复制标题
激素乳腺癌的转基因小鼠模型：优点和局限性。
DOI：
10.1016/j.jsbmb.2011.11.005
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Tekmal,RajeshwarR
中科院分区：
文献类型：
--
作者：
Kirma,NameerB;Tekmal,RajeshwarR
Mouse models of breast cancer, especially transgenic and knockout mice, have been established as valuable tools in shedding light on factors involved in preneoplastic changes, tumor development and malignant progression. The majority of mouse transgenic models develop estrogen receptor (ER) negative tumors. This is seen as a drawback because the majority of human breast cancers present an ER positive phenotype. On the other hand, several transgenic mouse models have been developed that produce ER positive mammary tumors. These include mice over-expressing aromatase, ERα, PELP-1 and AIB-1. In this review, we will discuss the value of these models as physiologically relevant in vivo systems to understand breast cancer as well as some of the pitfalls involving these models. In all, we argue that the use of transgenic models has improved our understanding of the molecular aspects and biology of breast cancer. Article from the Special issue on Steroids and cancer.
