Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia
Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia
复制标题
单核细胞趋化蛋白-1/CCL2在胃癌中的表达及其与肿瘤缺氧的关系
DOI：
10.3748/wjg.v20.i15.4421
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发表时间：
2014-04-21
影响因子：
4.3
通讯作者：
Huang, Gui-Chun
中科院分区：
文献类型：
--
作者：
Tao, Lei-Lei;Shi, Shu-Jing;Huang, Gui-Chun
目的：探讨CCL 2在胃癌中的表达、预后价值及其与肿瘤缺氧的关系。方法：分析68例胃癌患者的肿瘤组织，采用免疫组化方法检测肿瘤组织中CCL 2和缺氧诱导因子1 α（HIF-1 α）的表达。结果：CCL 2在66.2%（45/68）的胃癌组织中高表达; CCL 2在肿瘤组织中的表达分布与HIF-1 α的表达分布一致。胃癌组织中CCL 2高表达患者的总生存期较低[50.6 mo（95%CI：44.44-56.93）vs 64.6 mo（95%CI：60.27-68.94），P = 0.013]。CCL 2可能是胃癌独立的预后指标。(C)2014百世登出版集团有限公司有限公司All rights reserved.
AIM: To investigate the expression and prognostic value of CCL2 in gastric cancer, as well as its relationship with tumor hypoxia.METHODS: Tumor tissues from 68 gastric cancer patients (GC) were analyzed, and the expression of CCL2 and hypoxia-inducible factor 1 alpha (HIF-1 alpha) in tumor tissues was detected by immunohistochemistry. Statistical evaluations that were used included univariate log-rank tests of Kaplan-Meier curves and multivariate Cox regression model analysis.RESULTS: CCL2 was highly expressed in 66.2% (45/68) of gastric cancer specimens. The distribution of CCL2 expression in tumor tissue was consistent with that of HIF-1 alpha. Patients with high CCL2 expression in GC had a lower overall survival rate [50.6 mo (95% CI:44.44-56.93) vs 64.6 mo (95% CI: 60.27-68.94), P = 0.013].CONCLUSION: CCL2 expression correlates closely with HIF-1 alpha expression in gastric cancer. CCL2 may be an independent prognostic marker for GC. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.