Erythroblastic Island Macrophages Shape Normal Erythropoiesis and Drive Associated Disorders in Erythroid Hematopoietic Diseases.
Erythroblastic Island Macrophages Shape Normal Erythropoiesis and Drive Associated Disorders in Erythroid Hematopoietic Diseases.
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DOI：
10.3389/fcell.2020.613885
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发表时间：
2020
影响因子：
5.5
通讯作者：
Jiang Z
中科院分区：
文献类型：
--
作者：
Li W;Guo R;Song Y;Jiang Z
60多年前发现的成红细胞岛（EBI）是红细胞生成的特殊微环境。这个岛由中央巨噬细胞和周围发育中的红细胞组成。EBI巨噬细胞在支持红细胞生成假说的验证中受到了强烈的关注。这些研究大多集中在EBI巨噬细胞的鉴定和功能分析上，在鉴定和分离EBI巨噬细胞以及验证EBI巨噬细胞在红细胞生成中的潜在作用方面取得了重大进展。EBI巨噬细胞在小鼠和人中都表达促红细胞生成素受体（Epor），并且Epo在微环境中同时作用于红系细胞和EBI巨噬细胞，从而促进红细胞生成。脾龛巨噬细胞中受损的Epor信号传导显著抑制应激红系祖细胞的分化。此外，越来越多的证据表明，EBI巨噬细胞功能障碍可能导致某些红系血液学疾病。在这篇综述中，EBI巨噬细胞的异质性，鉴定和功能在稳态和应激条件下的红细胞生成概述。通过回顾历史数据，我们讨论了EBI巨噬细胞对红系造血系统疾病的影响，并提出了一个新的假说，即红系造血系统疾病是由EBI巨噬细胞驱动的。
Erythroblastic islands (EBIs), discovered more than 60 years ago, are specialized microenvironments for erythropoiesis. This island consists of a central macrophage with surrounding developing erythroid cells. EBI macrophages have received intense interest in the verifications of the supporting erythropoiesis hypothesis. Most of these investigations have focused on the identification and functional analyses of EBI macrophages, yielding significant progresses in identifying and isolating EBI macrophages, as well as verifying the potential roles of EBI macrophages in erythropoiesis. EBI macrophages express erythropoietin receptor (Epor) both in mouse and human, and Epo acts on both erythroid cells and EBI macrophages simultaneously in the niche, thereby promoting erythropoiesis. Impaired Epor signaling in splenic niche macrophages significantly inhibit the differentiation of stress erythroid progenitors. Moreover, accumulating evidence suggests that EBI macrophage dysfunction may lead to certain erythroid hematological disorders. In this review, the heterogeneity, identification, and functions of EBI macrophages during erythropoiesis under both steady-state and stress conditions are outlined. By reviewing the historical data, we discuss the influence of EBI macrophages on erythroid hematopoietic disorders and propose a new hypothesis that erythroid hematopoietic disorders are driven by EBI macrophages.
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