Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission
Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission
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DOI：
10.1007/bf02900219
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发表时间：
1997-08-01
影响因子：
4.7
通讯作者：
Berger, M
中科院分区：
文献类型：
--
作者：
Frommberger, UH;Bauer, J;Berger, M
据报道，在抑郁症和精神分裂症患者以及健康人中，在应激时，细胞因子如白细胞介素-6（IL-6）的浓度升高。在抑郁症（n = 12）和精神分裂症（n = 32）患者中，在急性疾病状态期间和入院后约8周缓解后测定白细胞介素-6血浆水平，并与健康对照进行比较：（n = 12）。根据DSM-III-R，通过结构化临床访谈（SCID）对患者进行诊断。采用蒙哥马利阿斯伯格抑郁评定量表（MADRS）和简明精神病评定量表（BPRS）评估抑郁症和精神分裂症的疾病严重程度。与对照组相比，抑郁症或精神分裂症急性期白细胞介素-6血浆浓度升高。缓解后，抑郁症和精神分裂症患者的IL-6浓度下降，与对照组无显著差异。Wen推测，抑郁症或精神分裂症急性期IL-6水平升高可能反映了一种非特异性应激反应。
The concentration of cytokines such as Interleukin-6 (IL-6) has been reported to be elevated In depressed and schizophrenic patients and, in healthy persons, upon stress, Interleukin-6 plasma levels were determined in depressed (n = 12) and schizophrenic (n = 32) patients during the acute state of illness and after remission at approximately 8 weeks after admission and were compared with healthy controls: (n = 12). Patients were diagnosed according to DSM-III-R by the Structured Clinical Interview (SCID). Severity of illness was assessed for depression by the Montgomery Asberg Depression Rating Scale (MADRS) and for schizophrenia by the Brief Psychiatric Rating Scale (BPRS). Interleukin-6 plasma concentrations were elevated during the acute state either of depression or of schizophrenia if compared to controls. After remission, IL-6 concentrations in depressed and in schizophrenic patients had decreased and did not differ significantly from controls. Wen hypothesize that the elevated IL-6 levels during the acute state of depression or schizophrenia may reflect an unspecific stress response.