Demonstration of motor imagery movement and phantom movement-related neuronal activity in human thalamus.
Demonstration of motor imagery movement and phantom movement-related neuronal activity in human thalamus.
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DOI：
10.1097/wnr.0b013e328342c98a
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发表时间：
2011-01-26
期刊：
影响因子：
1.7
通讯作者：
Lenz FA
中科院分区：
文献类型：
--
作者：
Anderson WS;Weiss N;Lawson HC;Ohara S;Rowland L;Lenz FA
功能成像研究表明，运动意象激活了人类前脑的多个结构。我们现在表明，截肢者的幻像运动和正常人的想象运动会引起几个人类丘脑核神经元的反应。这些包括躯体感觉核接受来自外周（腹侧尾侧- Vc）的输入，运动核接受来自小脑（腹侧中间- vim）和基底节区（腹侧口后- Vop）的输入。截肢者中有7个神经元表现出与幻影运动相关的活动（3个Vim， 2个Vop和2个Vc）。此外，3组对照中的7个神经元表现出与运动图像相关的活动（4个Vim和3个Vop）。这些研究是在通过丘脑刺激治疗幻肢痛、震颤和慢性疼痛的患者的单神经元记录过程中进行的。这些感觉核和运动核神经元的活动可能分别编码预期的感觉结果和计划运动的动态。
Functional imaging studies demonstrate that motor imagery activates multiple structures in the human forebrain. We now show that phantom movements in an amputee and imagined movements in intact subjects elicit responses from neurons in several human thalamic nuclei. These include the somatic sensory nucleus receiving input from the periphery (ventral caudal – Vc), and the motor nuclei receiving input from the cerebellum (ventral intermediate -Vim) and the basal ganglia (ventral oral posterior - Vop). Seven neurons in the amputee demonstrated phantom movement-related activity (3 Vim, 2 Vop, and 2 Vc). Additionally, seven neurons in a group of three controls demonstrated motor imagery-related activity (4 Vim, and 3 Vop). These studies were performed during single neuron recording sessions in patients undergoing therapeutic treatment of phantom pain, tremor, and chronic pain conditions by thalamic stimulation. The activity of neurons in these sensory and motor nuclei respectively may encode the expected sensory consequences and the dynamics of planned movements.