Generic rocuronium reduces withdrawal movements compared to original rocuronium under target-controlled infusion induction with propofol
Generic rocuronium reduces withdrawal movements compared to original rocuronium under target-controlled infusion induction with propofol
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DOI：
10.1007/s00540-020-02889-2
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发表时间：
2021-01-09
影响因子：
2.8
通讯作者：
Yamakage，Michiaki
中科院分区：
文献类型：
--
作者：
Hamada，Kosuke;Takahashi，Kazunobu;Yamakage，Michiaki
目的罗库溴铵引起的注射痛常常引起撤退运动，导致留置针意外中断。有报道称，与原罗库溴铵[日本东京MSD株式会社Esmeron®(Eslx®)]相比，使用新型解决方案的仿制药罗库溴铵可减少注射疼痛，然而，尚未有报告将镇静下的注射疼痛与最常使用的全身麻醉剂异丙酚进行比较。本研究采用靶控输注系统，比较异丙酚麻醉病人中罗库溴铵注射痛与普通罗库溴铵注射痛的差异。其中一组在丙泊酚镇静后使用靶控输液系统给予普通罗库溴铵。另一组在异丙酚麻醉后给予罗库溴铵。用该量表评估患者的戒断活动。主要结果是罗库溴铵给药后运动的总发生率。结果罗库溴铵组总的运动发生率(11%)明显低于罗库溴铵组(79%)(p<； )。罗库溴铵中重度活动发生率(0%)明显低于罗库溴铵(53%)(p<； 0.0 1)。结论罗库溴铵比罗库溴铵更适合靶控输注异丙酚麻醉诱导。
PurposeRocuronium-induced injection pain often causes withdrawal movements leading to accidental disruption of indwelling needles. Generic rocuronium (Maruishi Pharmaceutical Co., Ltd, Osaka, Japan) with a novel solution has been reported to reduce the injection pain compared to original rocuronium [Esmeron®(Eslax®), MSD Co. Ltd, Tokyo, Japan], however, no reports have compared the injection pain under sedation with propofol, the most frequently used general anesthetic. This study was carried out to compare the injection pain caused by generic rocuronium and that caused by original rocuronium in patients anesthetized by propofol with a target-controlled infusion system.MethodsForty patients were randomly assigned to two groups in this single-center, prospective, randomized, double-blind study. One group was administered generic rocuronium after sedation with propofol with a target-controlled infusion system. The other group was administered original rocuronium after anesthesia with propofol. Patient’s withdrawal movements were assessed with the scale. The primary outcome was the total incidence of movement after administration of rocuronium. Secondary outcome was the incidence of moderate or severe movement after administration of rocuronium.ResultsThe total incidence of movement after administration of generic rocuronium (11%) was significantly lower than that after the administration of original rocuronium (79%) (p< 0.01). The incidence of moderate or severe movement after administration of generic rocuronium (0%) was significantly lower than that after the administration of original rocuronium (53%) (p< 0.01).ConclusionGeneric rocuronium was considered more suitable than the original rocuronium for induction of anesthesia by propofol performed with a target-controlled infusion system.