Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract
Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract
复制标题
DOI：
10.1097/01.mog.0000181710.96904.58
复制
发表时间：
2005-11-01
影响因子：
2.5
通讯作者：
Reinecker, HC
中科院分区：
文献类型：
--
作者：
Niess, JH;Reinecker, HC
综述目的粘膜免疫系统不断监测肠道微生物区系。这种相互作用的结果是由树突状细胞的功能特性决定的，树突状细胞通过促进抗原采样和病原体识别以及天然宿主防御在免疫反应中发挥关键作用。最近的研究发现，对获得肠道抗原的不同机制有了深入的了解，并导致了对树突状细胞亚群器官特异性功能亚型的新认识。树突状细胞在肠道中不是一种罕见的细胞类型，而是作为一个广泛的网络分布在胃肠道的整个固有层中。不同的树突状细胞亚群可能与固有层和Peyer‘s斑块中的特定免疫功能有关。新发现的抗原获取途径，如跨上皮树突状细胞的形成，使树突状细胞能够直接进入肠腔，获得关于共生微生物和病原微生物的信息。树突状细胞是肠道免疫系统的关键调节者，具有引导肠道特异性T细胞迁移和控制的能力。摘要树突状细胞在肠道微生物区系与先天和获得性免疫系统之间复杂的相互作用中发挥重要作用，导致耐受和免疫。最近的贡献产生了重要的信息，可能有助于开发新的治疗方法来治疗炎症性肠病和肠道感染，以及新的免疫战略。
Purpose of review The mucosal immune system constantly surveys the intestinal microbiota. The outcome of this interaction is determined by the functional properties of dendritic cells, which play a key role in immune response by facilitating antigen sampling and pathogen recognition, as well as innate host defenses.Recent findings Recent advances have provided insight into the diverse mechanisms involved in the acquisition of intestinal antigens and led to a new appreciation of organ-specific functional subspecification of dendritic cell subsets. Dendritic cells are not a rare cell type in the intestine but populate the entire lamina propria of the gastrointestinal tract as an extensive network. Distinct dendritic cell subsets may be associated with specific immune functions in the lamina propria and Peyer's patches. Newly discovered routes of antigen acquisition, such as the formation of transepithelial dendrites, allow dendritic cells direct access to the intestinal lumen to obtain information about commensal and pathogenic microorganisms. Dendritic cells emerge as key regulators of the intestinal immune system with their ability to direct intestine-specific migration and control of T cells.Summary Dendritic cells play a major role in the complex interactions between the gut microbiota and the innate and adaptive immune system, leading to tolerance and immunity. Recent contributions have yielded important information that may aid in the development of novel therapeutic approaches to the treatment of inflammatory bowl disease and intestinal infections and to new immunization strategies.