Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice
Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice
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DOI：
10.1016/j.foodchem.2013.02.025
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发表时间：
2013-07-01
期刊：
影响因子：
8.8
通讯作者：
Miyazawa, Teruo
中科院分区：
文献类型：
--
作者：
Tsuduki, Tsuyoshi;Kikuchi, Ikuko;Miyazawa, Teruo
在这项研究中，在饮食诱导的肥胖小鼠模型中检查了 1-脱氧野尻霉素 (DNJ) 的抗肥胖作用。给肥胖小鼠施用桑葚 DNJ 12 周。结果，DNJ 降低了内脏脂肪重量和脂肪细胞大小。为了确定DNJ对脂质代谢的影响，测量了血浆和肝脏的脂质参数以及肝脏中与脂质代谢相关的几种分子的活性。 DNJ 激活 β-氧化系统，抑制肝脏中的脂质积累并降低血浆三酰甘油。由于认为β-氧化系统中激活的因子是脂联素，因此测量了血浆脂联素水平，结果显示血浆脂联素随着DNJ而增加。因此，提示DNJ促进血浆脂联素增加并激活β-氧化系统。总体而言，DNJ 通过增加脂联素来预防饮食引起的肥胖。 (c) 2013 Elsevier Ltd. 保留所有权利。
In this study, the anti-obesity effect of 1-deoxynojirimycin (DNJ) was examined in the diet-induced obese mouse model. Mulberry DNJ was administered to the obese mice for 12 weeks. As a result, DNJ decreased both the visceral fat weight and adipocyte size. To determine the influence of DNJ on lipid metabolism, lipid parameters of the plasma and the liver and the activities of several molecules related to lipid metabolism in the liver were measured. DNJ activated the beta-oxidation system, suppressed lipid accumulation in the liver and reduced plasma triacylglycerol. Since it was thought that the factor activated in the beta-oxidation system was adiponectin, plasma adiponectin levels were measured and it was shown that plasma adiponectin was increased with DNJ. Therefore, it was suggested that DNJ promoted an increase in plasma adiponectin and activated the beta-oxidation system. Overall, it was shown that DNJ prevents diet-induced obesity through an increase in adiponectin. (c) 2013 Elsevier Ltd. All rights reserved.