Theacrine, a purine alkaloid derived from Camellia assamica var. kucha, ameliorates impairments in learning and memory caused by restraint-induced central fatigue
Theacrine, a purine alkaloid derived from Camellia assamica var. kucha, ameliorates impairments in learning and memory caused by restraint-induced central fatigue
复制标题
茶碱 (Theacrine)，一种源自阿萨姆茶 (Camellia assamica var.) 的嘌呤生物碱。
DOI：
10.1016/j.jff.2015.05.003
复制
发表时间：
2015-06-01
影响因子：
5.6
通讯作者：
He, Rong-Rong
中科院分区：
文献类型：
--
作者：
Li, Yi-Fang;Chen, Min;He, Rong-Rong
阿萨姆红山茶苦茶是中国云南省的一种地方茶，那里的人们认为它的摄入可以缓解疲劳和疲劳。特咖宁是一种鲜为人知的嘌呤生物碱，最早是在这种茶中发现的。在此，我们发现，口服给药后，特咖宁（15 mg/kg）可被吸收到血液中并穿过血脑屏障。采用小鼠束缚应激模型，研究特咖宁抗中枢疲劳的作用及其机制。行为学实验结果表明，口服特咖宁（5，10，15 mg/kg）可明显逆转中枢疲劳引起的学习记忆障碍。此外，theacrine恢复了束缚小鼠大脑中与疲劳相关的神经递质的水平，包括5-羟色胺和多巴胺及其代谢产物。此外，我们发现特咖宁的抗疲劳作用与调节脑葡萄糖代谢和抑制磷酸二酯酶有关。(C)2015爱思唯尔有限公司版权所有。
Camellia assamica var. kucha is a local tea in the Yunnan province of China and people there believe its intake can relieve fatigue and their tiredness. Theacrine, a lesser-known purine alkaloid, was first discovered in this kind of tea. Here, we found that theacrine (15 mg/kg) could be absorbed into the blood and pass across the blood-brain barrier after oral administration. The effect and mechanism of theacrine on central fatigue were examined by employing a restraint stress model in mice. Results of behavioral tests suggested that oral administration of theacrine (5, 10, 15 mg/kg) significantly reversed learning and memory impairment caused by central fatigue. In addition, levels of fatigue-related neurotransmitters in the brains of restraint mice, including 5-hydroxytryptamine and dopamine as well as their metabolites, were restored by theacrine. Further, we found that the anti-fatigue effect of theacrine was associated with the regulation of brain glucose metabolism and the inhibition of phosphodiesterases. (C) 2015 Elsevier Ltd. All rights reserved.