Abnormalities in white matter connections between orbitofrontal cortex and anterior cingulate cortex and their associations with negative symptoms in schizophrenia: a DTI study.
Abnormalities in white matter connections between orbitofrontal cortex and anterior cingulate cortex and their associations with negative symptoms in schizophrenia: a DTI study.
复制标题
DOI：
10.1016/j.schres.2014.05.016
复制
发表时间：
2014-08
影响因子：
4.5
通讯作者：
Kubicki M
中科院分区：
文献类型：
--
作者：
Ohtani T;Bouix S;Hosokawa T;Saito Y;Eckbo R;Ballinger T;Rausch A;Melonakos E;Kubicki M
内侧眶额皮层（mOFC）和前扣带皮层（rACC）的吻侧部分是涉及情绪处理和决策的神经网络中重要的大脑区域，并且在社会行为和互动中发挥重要作用。考虑到精神分裂症的连接障碍假说，观察到的精神分裂症患者的情绪反应和社会行为异常可能与mOFC和rACC之间的连接异常有关。采用扩散张量成像（DTI）对27例慢性精神分裂症患者和26名健康对照进行了检查。使用随机纤维束成像检查双侧mOFC-rACC连接中的白色物质特性，这已被证明是检查相邻灰质区域之间的纤维束的最有效的DTI方法之一。与对照组相比，在患者的左前mOFC-rACC连接（p<0.0001）和双侧后mOFC-rACC连接（左：p<0.0001;右：p<0.0001）中观察到各向异性分数（FA）降低。此外，使用阴性症状评估量表，左后mOFC-rACC连接的FA减少与更严重的快感缺乏-社交障碍（R=-0.396，P=0.041）和无意志-冷漠（R=-0.426，P=0.027）相关。mOFC和rACC之间连接的白色异常与更严重的快感缺乏-社交性和无意志-冷漠相关，这表明这些脑区可能在理解精神分裂症患者的异常情绪反应和社会行为方面很重要。
The medial orbitofrontal cortex (mOFC) and rostral part of the anterior cingulate cortex (rACC) are brain regions that are important in the neural network involving emotional processing and decision making, as well as playing an important role in social behavior and interaction. Considering the schizophrenia dysconnectivity hypothesis, observed abnormalities in emotional response and social behavior in schizophrenia might be associated with connectivity abnormalities between mOFC and rACC. Twenty-seven patients with chronic schizophrenia and 26 healthy controls were examined using Diffusion Tensor Imaging (DTI). White matter properties in bilateral mOFC-rACC connections were examined using stochastic tractography, which has been shown to be among the most effective DTI methods for examining tracts between adjacent gray matter regions. Reductions in fractional anisotropy (FA) were observed in left anterior mOFC-rACC connections (p<0.0001), and bilateral posterior mOFC-rACC connections (left: p<0.0001; right: p<0.0001) in patients compared to controls. In addition, reduced FA in left posterior mOFC-rACC connections were associated with more severe anhedonia-asociality (R=−0.396, P=0.041) and avolition-apathy (R=−0.426, p=0.027) using the Scale for the Assessment of Negative Symptoms. White matter abnormalities within connections between mOFC and rACC are associated with more severe anhedonia-asociality and avolition-apathy, which suggest that these brain regions may be important in understanding abnormal emotional responses and social behavior in patients with schizophrenia.