Peroxisome proliferator activated receptor γ expression is reduced in the colonic mucosa of acromegalic patients.
Peroxisome proliferator activated receptor γ expression is reduced in the colonic mucosa of acromegalic patients.
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DOI：
10.1210/jc.87.5.2403
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发表时间：
2002-05-01
影响因子：
5.8
通讯作者：
Martino, E
中科院分区：
文献类型：
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作者：
Bogazzi, F;Ultimieri, F;Martino, E
肢端肥大症患者结肠息肉的患病率增加，这是由于血清胰岛素样生长因子（IGF）-I水平升高。这一过程的机制知之甚少。过氧化物酶体增殖物激活受体（PPAR）γ是一种调节脂肪细胞分化的核受体，在人结肠粘膜中高度表达，在结肠粘膜中诱导生长抑制和细胞分化。在本研究中，我们评估了22例肢端肥大症患者（Acro）和13例年龄和性别匹配的正常人（对照组）结肠粘膜活检样本中PPARgamma的表达。在Acro患者中，10例患有活动性未治疗疾病（AcroUntr），6例在手术后缓解（AcroRem），6例患有活动性疾病，正在接受生长抑素类似物治疗（AcroSMSa）。血清GH和IGF-I（平均值+/-SD）水平如下：AcroUntr：GH，36 ± 40 mug/l; IGF-I，769 ± 298 mug/l; AcroRem：GH，1.0 ± 1.3 mug/l; IGF-I，248 ± 96 mug/l; AcroSMSa：GH，7.8 ± 12 mug/l; IGF-I，429 ± 221 mug/l;对照：GH，0.8 ± 0.7 mug/l; IGF-I，203+/-67在对照中，PPARgamma mRNA的表达水平为15230+/-891转录物。AcroUntr患者有2750+/-688个PPARgamma转录本。（p
Acromegalic patients have an increased prevalence of colonic polyps, due to the elevated serum insulin like growth factor (IGF)-I levels. The mechanisms underlying this process are poorly understood. Peroxisome proliferator activated receptor (PPAR)gamma, a nuclear receptor that regulates adipocyte differentiation, is highly expressed in the human colonic mucosa, where it induces growth inhibition and cell differentiation. In the present study we evaluated the expression of PPARgamma in the bioptic samples of colonic mucosa from 22 patients with acromegaly (Acro) and 13 normal subjects (Controls) matched for age and sex. Among Acro patients, 10 had active, untreated disease (AcroUntr), 6 were in remission after surgery (AcroRem), and 6 had active disease under treatment with somatostatin analogs (AcroSMSa). Serum GH and IGF-I (mean+/-SD) levels were as follows: AcroUntr: GH, 36+/-40 mug/l; IGF-I, 769+/-298 mug/l; AcroRem: GH, 1.0+/-1.3 mug/l; IGF-I, 248+/-96 mug/l; AcroSMSa: GH, 7.8+/-12 mug/l; IGF-I, 429+/-221 mug/l; Controls: GH, 0.8+/-0.7 mug/l; IGF-I, 203+/-67 In the Controls the level of expression of PPARgamma mRNA was 15230+/-891 transcript. Patients with AcroUntr had 2750+/-688 transcript of PPARgamma. (p