Processed Meat and Risk of Renal Cell and Bladder Cancers
Processed Meat and Risk of Renal Cell and Bladder Cancers
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DOI：
10.1080/01635581.2018.1445764
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发表时间：
2018-03
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通讯作者：
V. Rosato;E. Negri;D. Serraino;M. Montella;M. Libra;P. Lagiou;G. Facchini;M. Ferraroni;A. Decarli;C. la Vecchia
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作者：
V. Rosato;E. Negri;D. Serraino;M. Montella;M. Libra;P. Lagiou;G. Facchini;M. Ferraroni;A. Decarli;C. la Vecchia
我们评估了加工肉类摄入量与肾细胞癌（RCC）和膀胱癌风险的关系。我们使用了两项意大利医院病例对照研究的数据，包括1，115例RCC病例和2，582例对照，以及1，417例膀胱癌病例和1，732例对照。我们用非条件logistic回归模型计算了优势比（OR）和95%置信区间（CI），并对主要混杂因素进行了调整。病例和对照组中加工肉类的平均消费量约为2份/周（50 g/份）。对于RCC和膀胱癌，每天增加10 g加工肉的OR分别为0.89（95% CI 0.84-0.94）和1.00（95% CI 0.94-1.06）。最高与最低消耗量的OR分别为0.80（95% CI 0.66-0.96）（RCC）和0.98（95% CI 0.80-1.21）（膀胱癌）。各协变量分层的OR一致。然而，对于膀胱癌，发现女性每日增加10 g的风险显著增加23%（95%CI 1.03-1.47），与男性记录的风险显著异质（OR 0.96，95%CI 0.90-1.02）。男性和女性之间的不一致结果以及男女之间缺乏关联表明，加工肉类与女性膀胱癌之间的明显关联不太可能是因果关系。
ABSTRACT We assessed the association of processed meat intake with the risk of renal cell carcinoma (RCC) and bladder cancer. We used data from two Italian hospital-based case-control studies, including 1,115 RCC cases and 2,582 controls, and 1,417 bladder cancer cases and 1,732 controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) with unconditional logistic regression models, adjusted for major confounders. The median consumption of processed meat in cases and controls was around 2 portions/week (50 g/portion). The ORs for a daily 10 g increment of processed meat was 0.89 (95% CI 0.84–0.94) for RCC and 1.00 (95% CI 0.94–1.06) for bladder cancer. The OR for the highest vs. the lowest consumption was 0.80 (95% CI 0.66–0.96) for RCC and 0.98 (95% CI 0.80–1.21) for bladder cancer. The ORs were consistent in strata of various covariates. For bladder cancer, however, a significant 23% excess risk was found in women (95% CI 1.03–1.47) for a daily increase of 10 g, significantly heterogeneous from the risk recorded in men (OR 0.96, 95% CI 0.90–1.02). The inconsistent results between men and women and the absence of association in both sexes combined indicate that the apparent association between processed meat and bladder cancer in women is unlikely to be causal.