Clinical implications of near-infrared fluorescence imaging in cancer.
Clinical implications of near-infrared fluorescence imaging in cancer.
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DOI：
10.2217/fon.09.109
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Kobayashi H
中科院分区：
文献类型：
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作者：
Kosaka N;Ogawa M;Choyke PL;Kobayashi H
近红外（NIR）荧光癌症成像由于其有利的特征（包括高空间分辨率、便携性、实时显示和荧光探针的多路复用使用的详细分子谱分析）而在临床前和临床应用于癌症患者的临床管理两者方面都是一个不断增长的领域。在这篇综述中，我们提出了近红外荧光成像的基本概念，并概述了其潜在的临床应用在体内癌症成像，包括癌症检测/表征，淋巴成像（前哨淋巴结检测）和手术/内窥镜引导。近红外荧光成像可以弥补传统成像方式的一些局限性，因此，它可以发挥重要的作用，癌症成像与其他方式结合在临床实践中。
Near-infrared (NIR) fluorescence cancer imaging is a growing field for both preclinical and clinical application to the clinical management for cancer patients due to its advantageous features, including a high spatial resolution, portability, real-time display and detailed molecular profiling with the multiplexed use of fluorescent probes. In this review, we present a basic concept of NIR fluorescence imaging and overview its potential clinical applications for in vivo cancer imaging, including cancer detection/characterization, lymphatic imaging (sentinel lymph node detection) and surgical/endoscopic guidance. NIR fluorescence imaging can compensate some limitations of conventional imaging modalities, and thus it could play an important role for cancer imaging combined with other modalities in clinical practice.