EFFECTS OF EXPOSURE TO 4-PPM NITROGEN-DIOXIDE IN HEALTHY AND ASTHMATIC VOLUNTEERS
EFFECTS OF EXPOSURE TO 4-PPM NITROGEN-DIOXIDE IN HEALTHY AND ASTHMATIC VOLUNTEERS
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DOI：
10.1080/00039896.1985.10545925
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
HACKNEY, JD
中科院分区：
文献类型：
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作者：
LINN, WS;SOLOMON, JC;HACKNEY, JD
健康和哮喘志愿者受试者（分别为N = 25和N = 23）在受控环境室中分别暴露于净化空气（对照）和4 ppm二氧化氮（NO2）两次。暴露持续75 min，包括轻度运动（通气率接近25 L/min）和重度运动（接近50 L/min）各15 min。与对照组相比，NO2暴露对正常或哮喘受试者的气道阻力、症状、心率、皮肤电导或自我报告的情绪状态没有统计学显著的不良影响。运动与两组受试者气道阻力的显著增加（P <0.001）相关，尽管正常人的增加很小。与对照组相比，两组的收缩压均随NO2暴露而显著降低（P <0.01）。这种效应，如果是真实的，可能与吸入的NO2形成血管舒张的亚硝酸盐或硝酸盐有关。呼吸反应的缺乏与以前在其他地方的发现形成对比;目前，这种不一致性尚无法解释。
Healthy and asthmatic volunteer subjects (N = 25 and N = 23, respectively) were exposed twice each to purified air (control) and to 4 ppm nitrogen dioxide (NO2) in a controlled-environment chamber. Exposures lasted 75 min, and included 15 min each of light exercise (ventilation rate near 25 L/min) and heavy exercise (near 50 L/min). Compared to control, NO2 exposure produced no statistically significant untoward effects on airway resistance, symptoms, heart rate, skin conductance, or self-reported emotional state in normal or asthmatic subjects. Exercise was associated with significantly (P < .001) increased airway resistance in both subject groups, although the increase in normals was small. In both groups, systolic blood pressure showed small but significant (P < .01) decreases with NO2 exposure, compared to control. This effect, if real, may relate to formation of a vasodilating nitrite or nitrate from inhaled NO2. The lack of respiratory response contrasts with previous findings elsewhere; at present, this inconsistency is unexplained.