Regulation and restricted expression of interstitial collagenase suggest a pivotal role in the initiation of menstruation
Regulation and restricted expression of interstitial collagenase suggest a pivotal role in the initiation of menstruation
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DOI：
10.1093/humrep/11.suppl_2.134
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发表时间：
1996-10-01
影响因子：
6.1
通讯作者：
Courtoy, PJ
中科院分区：
文献类型：
--
作者：
Marbaix, E;Kokorine, I;Courtoy, PJ
胶原酶是唯一能够在中性pH下切割纤维状胶原的三螺旋结构域的哺乳动物酶，纤维状胶原是子宫内膜细胞外基质的主要成分。间质胶原酶仅在月经前和月经期间在人子宫内膜中表达、分泌和活化，间质胶原酶的表达局限于子宫内膜功能层的破坏区域和子宫内膜的碎片，在子宫内膜组织中，结合性类固醇激素密切控制间质胶原酶的表达、分泌和激活，以及细胞外基质的保存，这些观察结果暗示这种蛋白酶在月经的开始中起关键作用。
Collagenases are the only mammalian enzymes able to cleave, at neutral pH, the triple helical domain of fibrillar collagens, major constituents of the extracellular matrix of the endometrium, Interstitial collagenase is expressed, secreted and activated in human endometrium only just before and during menstruation, The expression of interstitial collagenase is restricted to the areas of the functional layer of the endometrium which are breaking down and to fragments which have been shed, In endometrial explants, combined sex steroids tightly control the expression, secretion and activation of interstitial collagenase, as well as the preservation of the extracellular matrix, These observations imply a pivotal role for this proteinase in the initiation of menstruation.