Anticancer Chemodiversity of Ranunculaceae Medicinal Plants: Molecular Mechanisms and Functions.
Anticancer Chemodiversity of Ranunculaceae Medicinal Plants: Molecular Mechanisms and Functions.
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DOI：
10.2174/1389202917666160803151752
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发表时间：
2017-02
期刊：
影响因子：
2.6
通讯作者：
Xiao PG
中科院分区：
文献类型：
--
作者：
Hao DC;He CN;Shen J;Xiao PG
毛花科毛豆科植物包括至少62个属的2200多种植物，其中大部分是草本植物，自人类文明开始以来，一直被用于民间医学和世界各地的民族医学。毛茅科植物中含有多种药用植物代谢物，其中生物碱、萜类、皂苷、多糖等在体外和体内均显示出抗癌活性。最令人担忧的是两个顿悟分子，单萜类百里香酚和异喹啉生物碱黄连素。至少有17个属富含抗癌植物代谢产物。有些猫爪草科植物代谢产物诱导癌细胞周期停滞和凋亡或增强免疫活性，而另一些则抑制癌细胞的增殖、侵袭、血管生成和转移，或逆转肿瘤细胞的多药耐药，从而调节所有已知的癌症标志。这些植物代谢产物可能通过多种信号途径发挥其抗癌活性。此外，一些植物代谢产物的吸收、分布、代谢和排泄/毒性性质以及构效关系已被揭示，有助于早期药物的发现和开发。然而，目前尚缺乏对毛茅科植物代谢产物抗癌作用的分子机制和功能的全面综述。本文综述了猫爪草科药用植物抗癌化学和药理多样性的最新研究进展，重点介绍了抗癌植物代谢产物的分子机制和功能。基因表达谱和相关的组学平台(如基因组学、转录组学、蛋白质组学和代谢组学)可以揭示植物代谢产物对表型不同的癌细胞的不同作用。
The buttercup family, Ranunculaceae, comprising more than 2,200 species in at least 62 genera, mostly herbs, has long been used in folk medicine and worldwide ethnomedicine since the beginning of human civilization. Various medicinal phytometabolites have been found in Ranunculaceae plants, many of which, such as alkaloids, terpenoids, saponins, and polysaccharides, have shown anti-cancer activities in vitro and in vivo. Most concerns have been raised for two epiphany molecules, the monoterpene thymoquinone and the isoquinoline alkaloid berberine. At least 17 genera have been enriched with anti-cancer phytometabolites. Some Ranunculaceae phytometabolites induce the cell cycle arrest and apoptosis of cancer cells or enhance immune activities, while others inhibit the proliferation, invasion, angiogenesis, and metastasis, or reverse the multi-drug resistance of cancer cells thereby regulating all known hallmarks of cancer. These phytometabolites could exert their anti-cancer activities via multiple signaling pathways. In addition, absorption, distribution, metabolism, and excretion/toxicity properties and structure/activity relationships of some phytometabolites have been revealed assisting in the early drug discovery and development pipelines. However, a comprehensive review of the molecular mechanisms and functions of Ranunculaceae anti-cancer phytometabolites is lacking. Here, we summarize the recent progress of the anti-cancer chemo- and pharmacological diversity of Ranunculaceae medicinal plants, focusing on the emerging molecular machineries and functions of anti-cancer phytometabolites. Gene expression profiling and relevant omics platforms (e.g. genomics, transcriptomics, proteomics, and metabolomics) could reveal differential effects of phytometabolites on the phenotypically heterogeneous cancer cells.