Mitogenic neurotransmitters
Mitogenic neurotransmitters
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有丝分裂神经递质
作者：
M. Hanley
Michael R. Hanley control (see figure). The neuronal counterpart of a hypertrophic response would not be the induction of increased somatic volume, but rather would be the stimulation of increased cytoplasmic DESPITE significant progress in the des- to different signalling pathways, including surface area by enhancing process formacription of vertebrate neural cell lineages the negative regulation of adenyl cyclase tion and branching. This type of'trophic'and differentiation, little is known about through the GTP-binding protein Gi (ref. activity is not normally considered to be how the extensive proliferation of early 5), can drive the common output event of within the repertoire of neurotransmitter brain-precursor cells is coordinated, or cell proliferation. Indeed, it could well action, but the notion that trophic forms how non-neural cells are stimulated to turn out that all the main second-messen- of growth responses lie on one end of a divide during development or following ger pathways regulated by G-protein- continuum which has cell division at the injury. The question of neural cell mito- coupled receptors are conditionally other implies an appealing genetic unity to gens has focused on the actions of known mitogenic, albeit to varying extents. all forms of neural growth. growth factors, but the report of Capon Against this background, it is perhaps Neurotransmitter stimulation of proliand colleagues on page 146 of this issue'not suprising that two neural receptors, feration must also be dependent on some calls attention to a possibility r----------------------------, other cellular events which
