Cholecystokinin inhibits independent ingestion in neonatal rats.
Cholecystokinin inhibits independent ingestion in neonatal rats.
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胆囊收缩素抑制新生大鼠的独立摄入。
DOI：
10.1152/ajpregu.1988.255.1.r14
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
McHugh,PR
中科院分区：
文献类型：
--
作者：
Robinson,PH;Moran,TH;McHugh,PR
八肽胆囊收缩素（CCK-8）抑制独立的摄入的能力进行了研究，在8小时剥夺1至10日龄的幼鼠消耗牛奶从测试室的表面。CCK在剂量为100纳克/千克时显著减少了1日龄幼鼠的乳汁摄入量。抑制摄入的阈值有效剂量随年龄增加，直至10日龄。这种抑制的特异性通过三种方式进行评估。首先，行为学观察表明CCK抑制摄食行为，但不抑制非摄食行为。第二，脂肪酸CCK-8在抑制牛奶摄入方面无效。最后，CCK抑制牛奶摄入量刺激剥夺，但不影响脱水诱导的3日龄幼鼠的牛奶摄入。除了抑制摄入量，CCK抑制胃排空率的盐水试验餐在1日龄和3日龄的幼鼠，这种抑制的阈值剂量是相同的抑制摄入的阈值。这些结果表明，胃肠肽CCK是行为和生理活性的新生大鼠幼鼠和支持的胃抑制作用的CCK的饱腹感的行动。
The ability of the octapeptide of cholecystokinin (CCK-8) to inhibit independent ingestion was examined in 8-h deprived 1- to 10-day-old rat pups consuming milk from the surface of a test chamber. CCK significantly reduced the volume of milk ingested in 1-day-old rat pups at a dose of 100 ng/kg. The threshold effective dosage for inhibition of intake increased with age up to 10 days of age. The specificity of this suppression was evaluated in three ways. First, behavioral observation indicated that ingestive but not noningestive behaviors were suppressed by CCK. Second, desulfated CCK-8 was ineffective in suppressing milk ingestion. Finally, CCK inhibited milk intake stimulated by deprivation but did not affect dehydration-induced milk ingestion in 3-day-old rat pups. In addition to inhibiting intake, CCK inhibited the rate of gastric emptying of saline test meals in 1- and 3-day-old rat pups, and the threshold dosages for this suppression were identical to the thresholds for the inhibition of ingestion. These results indicate that the gastrointestinal peptide CCK is both behaviorally and physiologically active in newborn rat pups and support a role for gastric inhibition in the satiety action of CCK.