Strabismus and the Oculomotor System: Insights from Macaque Models
Strabismus and the Oculomotor System: Insights from Macaque Models
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DOI：
10.1146/annurev-vision-111815-114335
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Das, Vallabh E.
中科院分区：
文献类型：
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作者：
Das, Vallabh E.
在婴儿期破坏双眼视觉会导致斜视，并经常导致各种相关的视觉感觉缺陷和眼部异常。对这种疾病的研究得到了各种动物模型的发展，每种模型都有优点和缺点。与皮质结构中的双眼视觉响应的研究相比，对介导眼运动的错位和异常的神经眼结构的研究已经更新，并且这些研究已经表明，不同的脑区域密切参与驱动斜视状况的几个方面，包括水平错位、分离偏差、斜视的A和V模式、非共轭眼运动、眼球震颤和注视开关与正常发育的视觉眼动系统相比，视觉和眼动区域中的细胞的反应可能驱动感觉缺陷以及眼对准和眼动异常，其遵循校准中断、灵敏度较低和特异性较差的一般主题。
Disrupting binocular vision in infancy leads to strabismus and oftentimes to a variety of associated visual sensory deficits and oculomotor abnormalities. Investigation of this disorder has been aided by the development of various animal models, each of which has advantages and disadvantages. In comparison to studies of binocular visual responses in cortical structures, investigations of neural oculomotor structures that mediate the misalignment and abnormalities of eye movements have been more recent, and these studies have shown that different brain areas are intimately involved in driving several aspects of the strabismic condition, including horizontal misalignment, dissociated deviations, A and V patterns of strabismus, disconjugate eye movements, nystagmus, and fixation switch. The responses of cells in visual and oculomotor areas that potentially drive the sensory deficits and also eye alignment and eye movement abnormalities follow a general theme of disrupted calibration, lower sensitivity, and poorer specificity compared with the normally developed visual oculomotor system.