Incidence of type 1 and type 2 diabetes in adults and children in Kronoberg, Sweden
Incidence of type 1 and type 2 diabetes in adults and children in Kronoberg, Sweden
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DOI：
10.1016/j.diabres.2008.07.022
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发表时间：
2008-11-01
影响因子：
5.1
通讯作者：
Landin-Olsson, M.
中科院分区：
文献类型：
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作者：
Thunander, M.;Petersson, C.;Landin-Olsson, M.
对Kronoberg 3年内所有新诊断的糖尿病进行了登记，收集了1630/1666（97.8%）成年人的血液样本。GADab和/或ICA阳性和/或c肽< 0.25 nmol/L（0.7%）的患者为1型糖尿病，其余为2型糖尿病。0 ~ 19岁人群I型发病率为37.8(36.1 ~ 39.6,95%CI) / 10万/年，20 ~ 100岁人群为27.1(25.6 ~ 27.4)/ 10万/年，呈双峰型，0 ~ 9岁和50 ~ 80岁人群发病率高峰相同。成人2型发病378例（375-380例），儿童3.1例（2.6-3.6例）。成人中6.9%为1型，93.1%为2型。在抗体阳性的成人（101例）中，90%存在GADab， 71%存在ICA， 61%同时存在GADab和ICA。确认眼科接触为第二来源的比例为98%。在任何年龄组中，1型没有性别差异，在儿科亚组中差异较小。2型患者以40岁以上男性居多。1型糖尿病在儿童和成人中的发病率都非常高，50岁以上的儿童发病率也一样高。瑞典报告的2型糖尿病发病率最高，这可能与新的诊断标准、高病例发现率和许多老年人有关，但结果也可能反映了两种糖尿病发病率的真实增加。2008爱思唯尔爱尔兰有限公司版权所有。
All newly diagnosed diabetes in Kronoberg during 3 years was registered, with blood samples from 1630/1666 (97.8%) adults. Those positive for GADab and/or ICA and/or C-peptide < 0.25 nmol/L (0.7%) were classified as type 1 diabetes, the remaining as type 2. Incidence of type I in 0-19-year-olds was 37.8(36.1-39.6, 95%CI) and in 20-100 year-olds 27.1(25.6-27.4) per 100 000 and year, it was bimodal with equal peaks in 0-9 year-olds and in 50-80-year-olds. Adults had type 2 incidence 378 (375-380), children 3.1 (2.6-3.6). Among adults 6.9% had type 1 and 93.1% type 2. Among antibodypositive adults (n = 101), GADab were present in 90%, ICA in 71%, both GADab and ICA in 61%. Ophthalmology contact as second source was confirmed for 98%. There were no gender differences in type 1 in any age group, small ones in pediatric subgroups. in type 2 men predominated in ages above 40 years. Incidences of type 1 diabetes in both children and adults were very high and as high above age 50 years as in children. Incidence of type 2 was the highest reported from Sweden, to which new diagnostic criteria, a high degree of case-finding, and many elders, may have contributed, but results may also reflect a true increase in incidence of both types of diabetes. (C) 2008 Elsevier Ireland Ltd. All rights reserved.