Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD(+)-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase.
Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD(+)-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase.
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DOI：
10.3109/10409239609106581
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发表时间：
1996-04
影响因子：
6.5
通讯作者：
R T Okita;Janice Rice Okita
中科院分区：
文献类型：
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作者：
R T Okita;Janice Rice Okita
前列腺素E2和F2 α调节生殖组织中的许多生理功能，并且这些生物活性调节剂的浓度在妊娠期间增加。与妊娠期间循环中阿托兰定水平的增加相对应的是代谢这些药物的酶的增加。妊娠期间诱导的三种前列腺素代谢酶是NAD（+）依赖性15-羟基前列腺素脱氢酶（PGDH）、NADPH依赖性羰基还原酶和细胞色素P450依赖性前列腺素ω-或20-羟化酶。本文综述了这三种酶的生化特性、调节和可能的功能。
Prostaglandins E2 and F2 alpha regulate a number of physiological functions in reproductive tissues, and concentrations of these bioactive modulators increase during pregnancy. Corresponding to the increase in circulating levels of prostaglandins during pregnancy is an increase in enzymes that metabolize these agents. Three prostaglandin-metabolizing enzymes induced during pregnancy are NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH), NADPH-dependent carbonyl reductase, and cytochrome P450-dependent prostaglandin omega- or 20-hydroxylase. This review discusses the biochemical properties, regulation, and possible functions of these three enzymes.