Detection of chemical warfare agent degradation products in foods using liquid chromatography coupled to inductively coupled plasma mass spectrometry and electrospray ionization mass spectrometry.
Detection of chemical warfare agent degradation products in foods using liquid chromatography coupled to inductively coupled plasma mass spectrometry and electrospray ionization mass spectrometry.
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使用液相色谱法、电感耦合等离子体质谱法和电喷雾电离质谱法检测食品中的化学战剂降解产物。
DOI：
10.1016/j.chroma.2008.04.028
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Caruso,JosephA
中科院分区：
文献类型：
--
作者：
Kubachka,KevinM;Richardson,DouglasD;Heitkemper,DouglasT;Caruso,JosephA
探索了三种色谱分离与电感耦合等离子体质谱(ICPMS)联用分析化学战剂降解产物(CWADPs)。电感耦合等离子体的强大电离实际上是不依赖于基质的，因此，通常认为电喷雾电离(ESI)或大气压化学电离质谱仪分析样品矩阵过于复杂，几乎不需要样品制备。分析的重点是检测食品基质中的CWADPs，因为它们可能是恐怖分子污染的工具。由于电感耦合等离子体质谱对31P的特异性检测，将感兴趣的分析物从其他含磷干扰物(H3PO4)中分离出来是每次分离的关键部分。在H3PO4存在下，使用所述方法分离了多达10个CWADP，检测下限为百万分之几的低水平。此外，还定制了一种与电感耦合等离子体质谱仪和电喷雾质谱仪兼容的方法，使结构验证成为可能。
The following work presents the exploration of three chromatographic separations in combination with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of chemical warfare agent degradation products (CWADPs). The robust ionization of ICP is virtually matrix independent thus enabling the examination of sample matrices generally considered too complicated for analysis by electrospray ionization (ESI) or atmospheric pressure chemical ionization MS with little to no sample preparation. The analysis was focused on detecting CWADPs in food matrices, as they present possible vehicles for terrorist contamination. Due to the specific detection of31P by ICP-MS, resolution of analytes of interest from other P-containing interferences (H3PO4) was a crucial part of each separation. Up to 10 CWADPs were separated in the presence of H3PO4with detection limits in the low part per billion levels using the methods described. Additionally, one method was tailored to be compatible with both ICP-MS and ESI-MS making structural verification possible.