Telocytes in Human Term Placenta: Morphology and Phenotype
Telocytes in Human Term Placenta: Morphology and Phenotype
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DOI：
10.1159/000319467
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发表时间：
2010-01-01
影响因子：
2.7
通讯作者：
Faussone-Pellegrini, Maria-Simonetta
中科院分区：
文献类型：
--
作者：
Suciu, Laura;Popescu, Laurentiu M.;Faussone-Pellegrini, Maria-Simonetta
近年来，在消化器官和消化外器官中发现了一种新的细胞类型-间质cajal样细胞（ICLC）。最近已将其名称改为远端细胞（TC），其典型的细长突起已被命名为端足细胞（TP）。为了支持TC也可能存在于人胎盘的假设，并补充现有的信息，我们提供了关于人足月胎盘绒毛核中TC的超微结构、免疫表型、分布及其与周围基质细胞相互作用的证据。我们使用相差显微镜、半薄切片光学显微镜、透射电子显微镜、免疫组织化学和组织切片或细胞培养的免疫荧光，遵循预先建立的诊断算法。透射电子显微镜显示类似TC的细胞，大多数（76%）具有2-3个非常薄的长过程（数十至数百微米），口径不均匀(
In the last few years, a new cell type - interstitial Cajal-like cell (ICLC) - has been described in digestive and extra-digestive organs. The name has recently been changed to telocytes (TC) and their typical thin, long processes have been named telopodes (TP). To support the hypothesis that TC may also be present in human placenta and add to the information already available, we provide evidence on the ultrastructure, immunophenotype, distribution, and interactions with the surrounding stromal cells of TC in the villous core of human term placenta. We used phase-contrast microscopy, light microscopy of semithin sections, transmission electron microscopy, immunohistochemistry, and immunofluorescence of tissue sections or cell cultures, following a pre-established diagnostic algorithm. Transmission electron microscopy showed cells resembling TC, most (similar to 76%) having 2-3 very thin, long processes (tens to hundreds of micrometers), with an uneven calibre (