Identification of Pseudopolymorphism of Magnesium Stearate by Using Low-Frequency Raman Spectroscopy
Identification of Pseudopolymorphism of Magnesium Stearate by Using Low-Frequency Raman Spectroscopy
复制标题
低频拉曼光谱鉴定硬脂酸镁的假多晶型
DOI：
--
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Y. Goda
中科院分区：
文献类型：
--
作者：
T. Koide;T. Fukami;H. Hisada;Motoki Inoue;J. Carriere;R. Heyler;N. Katori;H. Okuda;Y. Goda
目前市场上可买到的硬脂酸镁（Mg-St）具有多种特性，包括假多态性、脂肪酸中硬脂酸的相对含量和粒度。Mg-St的这些特性会影响药品的生产过程，因此，有必要控制供应商提供的Mg-St的质量。本研究的目的是评价拉曼光谱低频区对Mg-St伪多态性的鉴别作用。采用粉末x射线衍射（PXRD）和热重差热分析（TG-DTA）对10个不同供应商的Mg-St样品进行了测定，以确定Mg-St的伪多态性。然后我们研究了它们的拉曼光谱（包括低频区）与伪多态的关系。结果将Mg-St分为四种类型，即单水合、二水合和三水合及其混合物。拉曼光谱的常规区域(大于200…
Magnesium stearate (Mg-St), which is currently available on the market, has a wide variety of properties, including pseudopolymorphism, relative content of stearic acid in fatty acid, and particle size. These properties of Mg-St influence manufacturing processes of pharmaceutical products, and therefore, it is necessary to control the quality of Mg-St from suppliers. The purpose of this study was to evaluate the low-frequency region of Raman spectroscopy for identification of pseudopolymorphism in Mg-St. Ten samples of Mg-St obtained from different suppliers were measured by powder X-ray diffraction (PXRD) and thermogravimetry and differential thermal analysis (TG-DTA) to identify the pseudopolymorphism of Mg-St. Then we investigated the relationship between their Raman spectra, including the low-frequency region, and pseudopolymorphism. The results were categorized as four types of Mg-St, namely, mono-, di-, and trihydrate and their mixture. The conventional region of the Raman spectrum (greater than 200...
影响因子：
3.4
作者：
Roy S;Chamberlin B;Matzger AJ
通讯作者：
Matzger AJ