Immunologic paralysis produced in mice by Klebsiella pneumoniae type 2 polysaccharide.
Immunologic paralysis produced in mice by Klebsiella pneumoniae type 2 polysaccharide.
复制标题
2 型肺炎克雷伯菌多糖在小鼠体内产生免疫麻痹。
DOI：
10.4049/jimmunol.90.1.121
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发表时间：
1963
影响因子：
4.4
通讯作者：
M. Shaffer
中科院分区：
文献类型：
--
作者：
B. Batshon;H. Baer;M. Shaffer
注射不同量的肺炎克雷伯氏菌2型多糖的小鼠随后在不同的时间间隔后用活的同源生物体进行攻击。在三种多糖制剂中，一种基本无毒且无免疫性;另外两种的抗原性大致相同。在接受2.5 µg后一种制剂的动物组中，存活动物比例高于750 µg组。在给予2.5 μg多糖的小鼠血清中，在5天内检测到被动保护性抗体，而在给予750 μg多糖的动物血清中，这种抗体在60天前不明显-此时可比动物的主动保护程度正在减弱。
Mice injected with varying amounts of Klebsiella pneumoniae type 2 polysaccharide were subsequently challenged with living homologous organisms after varying intervals of time. Of three preparations of polysaccharide, one was essentially nontoxic and nonimmunizing; the other two were approximately equal in antigenicity. In the groups of animals receiving 2.5 µg of these latter preparations, there was a greater proportion of survivors than in groups given 750 µg. Passively protective antibodies were detected within 5 days in the serum of mice given 2.5 µg, whereas in the serum of animals given 750 µg of polysaccharide such antibodies were not evident before 60 days—a time when the degree of active protection in comparable animals was waning.