Clinical view on the importance of dendritic cells in asthma.
Clinical view on the importance of dendritic cells in asthma.
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DOI：
10.1586/1744666x.2013.837260
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发表时间：
2013-10
影响因子：
4.4
通讯作者：
Agrawal DK
中科院分区：
文献类型：
--
作者：
Gaurav R;Agrawal DK
过敏性哮喘以呼吸道高反应性和炎症为特征，在无控制的病例中可导致气道重塑。特应性表型的遗传易感性在哮喘的病理生理学中起着重要作用。然而，由于表观遗传因素和环境刺激在激发免疫反应中的巨大作用，其潜在的病理生理机制是复杂的。在过敏性哮喘中，树突状细胞是主要的抗原提呈细胞和免疫反应的启动者。它们的表型受多种因素的引导，可能决定了对过敏或耐受性反应的免疫反应。局部细胞因子环境、微生物群的参与以及免疫细胞之间的相互作用增加了免疫反应的命运。除了过敏原暴露，这些因素还调节DC的表型和功能。在这篇文章中，许多与DC募集和激活相关的因素和途径在过敏性哮喘的病理生理学中以临床和翻译的方式被提出。
Allergic asthma is characterized by airway hyperresponsiveness and inflammation and may lead to airway remodeling in uncontrolled cases. Genetic predisposition to an atopic phenotype plays a major component in the pathophysiology of asthma. However, with tremendous role of epigenetic factors and environmental stimuli in precipitating an immune response, the underlying pathophysiological mechanisms are complicated. Dendritic cells are principal antigen presenting cells and initiators of the immune response in allergic asthma. Their phenotype, guided by multiple factors may dictate the immune reaction to an allergic or tolerogenic response. Involvement of the local cytokine milieu, microbiome and interplay between immune cells add dimension to the fate of immune response. In addition to allergen exposure, these factors modulate DC phenotype and function. In this article, integration of many factors and pathways associated with the recruitment and activation of DCs in the pathophysiology of allergic asthma is presented in a clinical and translational manner.