Altered perceptual binding in Gilles de la Tourette syndrome
Altered perceptual binding in Gilles de la Tourette syndrome
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DOI：
10.1016/j.cortex.2016.07.015
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发表时间：
2016-10-01
期刊：
影响因子：
3.6
通讯作者：
Muenchau, Alexander
中科院分区：
文献类型：
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作者：
Beste, Christian;Tuebing, Jennifer;Muenchau, Alexander
抽动秽语综合征（GTS）是一种常见的多方面神经精神疾病。GTS的研究传统上集中在这些患者运动过程变化的潜在机制上。然而，人们对GTS相关的感觉现象越来越感兴趣。根据事件编码理论，感觉刺激不仅具有表征功能，还具有动作相关功能。在目前的研究中，我们使用TEC框架来检查是否感知功能的处理方式是改变GTS。结果表明，GTS患者和健康对照组之间的基本感知过程不同，这可能是理解这种疾病的核心。知觉对象的细节或特征在GTS中较少被约束，这表明知觉特征的整合在GTS中被衰减。行为研究结果是无关的病人的特点，这意味着他们可能代表特质异常。GTS中感知处理的改变可能是由于在这些患者中反复描述的顶叶区域与其他大脑区域的长距离连接不足。(C)2016爱思唯尔有限公司版权所有
Gilles de la Tourette syndrome (GTS) is a common multifaceted neuropsychiatric disorder. Research in GTS has traditionally focussed on mechanisms underlying changes in motor processes in these patients. There is, however, growing interest in GTS related sensory phenomena. According to the Theory of Event-coding (TEC), sensory stimuli do not only serve representational functions but also action-related functions. In the current study, we use the TEC framework to examine whether the way perceptual features are processed is altered in GTS. The results show that basic perceptual processes differ between GTS patients and healthy controls which might be central for the understanding of this disorder. Details or features of perceptual objects were less bound in GTS suggesting that perceptual features integration is attenuated in them. Behavioural findings were unrelated to patient characteristics implying that they might represent trait abnormalities. It is possible that altered perceptual processing in GTS is due to a long-range under-connectivity of parietal areas with other brain regions repeatedly been described in these patients. (C) 2016 Elsevier Ltd. All rights reserved.