Modification and validation of the Birmingham Vasculitis Activity Score (version 3)
Modification and validation of the Birmingham Vasculitis Activity Score (version 3)
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DOI：
10.1136/ard.2008.101279
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发表时间：
2009-12-01
影响因子：
27.4
通讯作者：
Luqmani, R. A.
中科院分区：
文献类型：
--
作者：
Mukhtyar, C.;Lee, R.;Luqmani, R. A.
背景资料：使用伯明翰血管炎活动性评分（BVAS）的综合多系统临床评估广泛用于系统性血管炎的治疗研究。广泛使用表明需要修改该仪器。以前的版本的BVAS已经修订，根据使用和审查由一个专家committee.Objective：修改和验证版本3的BVAS在系统性vasculitis.Methods：新版本的BVAS进行了测试，在一个前瞻性的横断面研究的患者vasculitis.Results：项目的数量从66减少到56。新发/恶化疾病和持续性疾病的子评分是统一的。在313例系统性血管炎患者中，（v.3）与治疗决定相关（斯皮尔曼r（s）= 0.66，95% CI 0.59 - 0.72），版本2的BVAS 1（r（s）= 0.94，95% CI 0.92 - 0.96），持续性疾病患者中版本2的BVAS 2（r（s）= 0.60，95% CI 0.21 - 0.83）、C反应蛋白水平（r（s）= 0.43，95% CI 0.31 - 0.54）、医生总体评估（r（s）= 0.91，95% CI 0.89 - 0.93）和血管炎活动指数（r（s）= 0.88，95% CI 0.86 - 0.91）。再现性和重复性的组内相关系数分别为0.96（95% CI 0.95 - 0.97）和0.96（95% CI 0.92 - 0.97）。在39名患者中，在诊断时和3个月时再次评估，BVAS（v. 3）下降了17（95%CI 15 - 19）个单位（p
Background: Comprehensive multisystem clinical assessment using the Birmingham Vasculitis Activity score (BVAS) is widely used in therapeutic studies of systemic vasculitis. Extensive use suggested a need to revise the instrument. The previous version of BVAS has been revised, according to usage and reviewed by an expert committee.Objective: To modify and validate version 3 of the BVAS in patients with systemic vasculitis.Methods: The new version of BVAS was tested in a prospective cross-sectional study of patients with vasculitis.Results: The number of items was reduced from 66 to 56. The subscores for new/worse disease and persistent disease were unified. In 313 patients with systemic vasculitis, BVAS(v. 3) correlated with treatment decision (Spearman's r(s) = 0.66, 95% CI 0.59 to 0.72), BVAS1 of version 2 (r(s) = 0.94, 95% CI 0.92 to 0.96), BVAS2 of version 2 in patients with persistent disease (r(s) = 0.60, 95% CI 0.21 to 0.83), C-reactive protein levels (r(s) = 0.43, 95% CI 0.31 to 0.54), physician's global assessment (r(s) = 0.91, 95% CI 0.89 to 0.93) and vasculitis activity index (r(s) = 0.88, 95% CI 0.86 to 0.91). The intraclass correlation coefficients for reproducibility and repeatability were 0.96 (95% CI 0.95 to 0.97) and 0.96 (95% CI 0.92 to 0.97), respectively. In 39 patients assessed at diagnosis and again at 3 months, the BVAS(v. 3) fell by 17 (95% CI 15 to 19) units (p