Evidence of segment reassortment in Crimean-Congo haemorrhagic fever virus
Evidence of segment reassortment in Crimean-Congo haemorrhagic fever virus
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DOI：
10.1099/vir.0.80121-0
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发表时间：
2004-10-01
影响因子：
3.8
通讯作者：
Clegg, C
中科院分区：
文献类型：
--
作者：
Hewson, R;Gmyl, A;Clegg, C
从乌兹别克斯坦、伊拉克和巴基斯坦分离的克里米亚-刚果出血热（CCHF）病毒的三个独立毒株的小（S）和中（M）片段的完整核苷酸序列已经确定。还获得了另外两株CCHF病毒的部分S和M节段序列以及五株CCHF病毒的部分大节段序列。这些数据已被编译，并与已发表的全长和部分序列的其他CCHF病毒株进行了比较。分析病毒株的完整和部分的S和M节段序列是可用的，揭示了一些菌株的系统发育分组这两个部分之间的不同。本报告中提供的数据表明，这种差异不是重组的结果，而是某些病毒谱系中发生的重配事件的结果。虽然在布尼亚病毒科的其他属中有描述，但这是第一次报道发生在内罗病毒属中的片段重配。
The complete nucleotide sequences of the small (S) and medium (M) segments of three independent strains of Crimean-Congo haemorrhagic fever (CCHF) virus isolated in Uzbekistan, Iraq and Pakistan have been determined. Partial S and M segment sequences from two additional strains and partial large segment sequences from five strains of CCHF virus have also been obtained. These data have been compiled and compared with published full-length and partial sequences of other CCHF virus strains. Analysis of virus strains for which complete and partial S and M segment sequences are available reveals that the phylogenetic grouping of some strains differ between these two segments. Data provided in this report suggest that this discrepancy is not the result of recombination, but rather the consequence of reassortment events that have occurred in some virus lineages. Although described in other genera of the Bunyaviridae family, this is the first report of segment reassortment occurring in the Nairovirus genus.