Polo-like kinases: conservation and divergence in their functions and regulation
Polo-like kinases: conservation and divergence in their functions and regulation
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DOI：
10.1038/nrm2675
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发表时间：
2009
影响因子：
112.7
通讯作者：
Vincent Archambault;D. Glover
中科院分区：
文献类型：
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作者：
Vincent Archambault;D. Glover
Polo-like kinase(Plk)是M期的有力调节者，从酵母到人类都是保守的。它们在有丝分裂进入、纺锤体极功能和胞质分裂中的作用是广泛保守的，尽管这些过程在不同的生物体中存在物理和分子上的差异。Plks的特征是它们的Polo-box结构域，它介导蛋白质的相互作用。它们还受磷酸化、蛋白分解和转录的控制，这取决于生物环境。Plks现在被认为将细胞分裂与发育过程联系起来，并在分化的细胞中发挥作用。通过对不同生物体之间PLK功能和调节的比较，可以洞察细胞分裂的丰富变异。
Polo-like kinases (Plks) are potent regulators of M phase that are conserved from yeasts to humans. Their roles in mitotic entry, spindle pole functions and cytokinesis are broadly conserved despite physical and molecular differences in these processes in disparate organisms. Plks are characterized by their Polo-box domain, which mediates protein interactions. They are additionally controlled by phosphorylation, proteolysis and transcription, depending on the biological context. Plks are now recognized to link cell division to developmental processes and to function in differentiated cells. A comparison of Plk function and regulation between organisms offers insight into the rich variations of cell division.