Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission.
Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission.
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与疼痛传递有关的外周感觉神经节交叉兴奋
DOI：
10.3390/toxins7082906
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发表时间：
2015-08-04
期刊：
影响因子：
4.2
通讯作者：
Matsuka Y
中科院分区：
文献类型：
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作者：
Omoto K;Maruhama K;Terayama R;Yamamoto Y;Matsushita O;Sugimoto T;Oguma K;Matsuka Y
尽管缺乏突触接触，但信号传递过程中感觉神经节神经元的交叉兴奋被认为是化学介导的，并且在慢性疼痛状态下出现增加。在本研究中，我们在神经性疼痛动物模型中，通过将A型肉毒杆菌神经毒素（BoNT/A）直接应用于感觉神经节来调节感觉神经元中的神经递质释放，并评估了这种治疗对恶性反应的影响。单侧坐骨神经压迫（SNE）降低了同侧后爪对机械刺激的退出阈值，降低了后爪对热刺激的退出潜伏期。BoNT/A直接应用于同侧L4背根神经节（DRG），定位于DRG的细胞体，逆转了sne诱导的2天内BoNT/A给药后戒断阈值的下降。本研究结果提示，感觉神经节内的神经递质释放参与疼痛相关信号传递的调控。
Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.