Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia?
Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia?
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在低氧血症的运动过程中，人体股四头肌血流量峰值是否会更高？
DOI：
10.1152/ajpheart.1986.251.5.h1038
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Christensen,NJ
中科院分区：
文献类型：
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作者：
Rowell,LB;Saltin,B;Kiens,B;Christensen,NJ
通过热稀释法测量了6名男性在休息和动态运动[20、38和42.5-60 W（峰值负荷）]期间股四头肌的血流量（Q），这些运动仅限于正常氧（N）和低氧血症（H; 10- 11%O2）下的一条腿的股四头肌。无一例外地，Q和股四头肌血管传导性在H组较高。当功率超过20 W时，动脉平均压、乳酸、去甲肾上腺素和肾上腺素均升高。N组的Q值分别为0.25、3.28、4.27和5.81 l/min（静息至峰值运动），H组的Q值分别为0.25、4.08、5.24和6.58 l/min。每100 g肌肉（股四头肌质量= 2.2 kg）的峰值Q值分别为273.3（N）和308.8 ml/min（H）。四头肌VO 2（Q X股骨A-VO 2差值）分别为25、388、556和771 ml/min（N）以及25、390、556和743（H中较低的峰值载荷）-净机械效率为23%。肌肉O2输送（Q X动脉O2含量）不受H的影响;在H中O2提取下降，但在所有工作负荷下股静脉O2含量保持在6（N）和5 ml/100 ml（H）附近，与全身运动中低得多的值形成对比。在H肌中，当活动肌肉的质量太小而不能压倒心脏的泵送能力时，Q可以上升到甚至更高的峰值，而没有明显的限制。
Blood flow (Q) to quadriceps muscles was measured by thermal dilution in six men during rest and dynamic exercise [20, 38, and 42.5-60 W (peak load)] restricted to quadriceps of one leg in normoxia (N) and hypoxemia (H; 10-11% O2). Without exception Q and quadriceps vascular conductance were higher in H. Arterial mean pressure, lactate, norepinephrine, and epinephrine all rose when work exceeded 20 W. Q in N was 0.25, 3.28, 4.27, and 5.81 l/min (rest to peak exercise) and in H was 0.25, 4.08, 5.24, and 6.58 l/min. Peak Q per 100 grams of muscle (quadriceps mass = 2.2 kg) was 273.3 (N) and 308.8 ml/min (H). Quadriceps VO2 (Q X femoral A-VO2 difference) was 25, 388, 556, and 771 ml/min (N) and 25, 390, 556, and 743 (lower peak load in H)-net mechanical efficiency was 23%. Muscle O2 delivery (Q X arterial O2 content) was unaffected by H; O2 extraction fell in H but femoral venous O2 content remained near 6 (N) and 5 ml/100 ml (H) at all workloads, in contrast to much lower values in whole body exercise. In H muscle Q can rise to even higher peak values, without apparent limit, when the mass of active muscle is too small to overwhelm the pumping capacity of the heart.