REGIONALLY SELECTIVE ROLES OF THE RATS STRIATUM IN MODALITY-SPECIFIC DISCRIMINATION-LEARNING AND FORELIMB REACHING
REGIONALLY SELECTIVE ROLES OF THE RATS STRIATUM IN MODALITY-SPECIFIC DISCRIMINATION-LEARNING AND FORELIMB REACHING
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DOI：
10.1016/0166-4328(90)90140-a
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发表时间：
1990-03-26
影响因子：
2.7
通讯作者：
CYR, J
中科院分区：
文献类型：
--
作者：
PISA, M;CYR, J
在十字形迷宫中训练内侧纹状体或外侧纹状体有Ibotenate损伤的大鼠的前肢到达任务和获得、保持和逆转转弯（左-右）辨别或亮度（黑-白）辨别。与对照组相比，损伤内侧纹状体的大鼠在翻转辨别中表现出可靠的、模态选择性的损害，但在到达方面没有明显的损害。与此相反，大鼠侧纹状体病变表现出显着的损害前肢达到，但没有逆转的歧视。无论是内侧或外侧病变显着影响收购和保留这两个歧视。研究结果表明，在监测方向反应的内侧纹状体的主导作用，确认区域特定的作用，外侧纹状体达到，并解释支持的假设，平行的运动和认知前脑电路，包括独特的区域的纹状体。
Rats with ibotenate lesions of either the medial striatum or the lateral striatum were trained in a forelimb reaching task and in acquisition, retention and reversal of either turn (left-right) discrimination or brightness (black-white) discrimination in a cross-shape maze. Compared with the controls, the rats with lesions of the medial striatum showed a reliable, modality-selective impairment in reversal of turn discrimination, but no significant impairment of reaching. In contrast, the rats with lateral striatal lesions showed a significant impairment of forelimb reaching, but not of reversal of either discriminations. Neither medial nor lateral lesions significantly affected acquisition and retention of both discriminations. The findings indicate a predominant role of the medial striatum in monitoring of directional responses, confirm the regionally specific role of the lateral striatum in reaching, and are interpreted to support the hypothesis of parallel motor and cognitive forebrain circuits comprising distinctive regions of the striatum.