Correlation of scalp EEG and 1H-MRS metabolic abnormalities in temporal lobe epilepsy.
Correlation of scalp EEG and 1H-MRS metabolic abnormalities in temporal lobe epilepsy.
复制标题
颞叶癫痫头皮脑电图与 1H-MRS 代谢异常的相关性。
DOI：
10.1046/j.1528-1157.2001.25999.x
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发表时间：
2001
期刊：
影响因子：
5.6
通讯作者：
Kuzniecky,R
中科院分区：
文献类型：
--
作者：
Maton,B;Gilliam,F;Sawrie,S;Faught,E;Hugg,J;Kuzniecky,R
目的：将颞叶癫痫 (TLE) 发作间期尖峰野和癫痫发作区域与 1H-MRS 异常的分布联系起来，提高我们对 1H-MRS 异常临床意义的理解。方法：对 31 名连续 TLE 患者进行头皮脑电图 (EEG) 监测和质子磁共振波谱 (1H-MRS) 结果进行相关。结果：基于偏侧化 1H-MRS 的海马异常与95% 的患者有单侧发作间期尖峰，侧化侧 (90%) 具有高度一致性。在 64% 具有正常或双侧发作间期脑电图尖峰的患者中，1H-MRS 提供了侧化信息。双侧 1H-MRS 异常（无论有或没有偏侧化）的发生率是双颞 EEG 尖峰的 3 倍。与没有这种 EEG 分布的患者 (18%) 相比，具有前颞部 EEG 尖峰的患者 (50%) 的 1H-MRS 前部异常更为常见。 1H-MRS 异常的分布和 EEG 癫痫发作区域之间也存在类似的关联。结论：我们的结果显示 1H-MRS 的分布和 EEG 异常之间有中等程度的一致性。1H-MRS 比 EEG 更频繁地识别主要癫痫病灶对侧的异常，并且可以为非偏侧性发作间期 EEG 患者提供偏侧化信息。
Purpose:To correlate the interictal spike field and region of seizure onset with the distribution of1H‐MRS abnormalities in temporal lobe epilepsy (TLE) and improve our understanding of the clinical significance of1H‐MRS abnormalities.Methods:Scalp electroencephalogram (EEG) monitoring and proton magnetic resonance spectroscopy (1H‐MRS) results were correlated in 31 consecutive patients with TLE.Results:Lateralized1H‐MRS–based hippocampal abnormalities were recorded in 95% of the patients with unilateral interictal spikes, with a high degree of concordance for the lateralization side (90%). In 64% of the patients with normal or bilateral interictal EEG spikes,1H‐MRS provided lateralizing information. Bilateral1H‐MRS abnormalities, with or without lateralization, were 3 times more frequent than bitemporal EEG spikes. Anterior predominance of the1H‐MRS abnormalities was more frequent in patients with anterior temporal EEG spiking (50%), than in patients without this EEG distribution (18%). Similar association was noted between distribution of1H‐MRS abnormalities and region of EEG seizure onset.Conclusions:Our results show a moderate level of concordance between the distribution of1H‐MRS and EEG abnormalities.1H‐MRS identifies abnormalities contralateral to the predominant seizure focus more often than does EEG and may provide lateralizing information in patients with nonlateralizing interictal EEG.