Observations on the development of the febrile response to pyrogens in sheep.
Observations on the development of the febrile response to pyrogens in sheep.
复制标题
绵羊热原发热反应发展的观察。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
G. V. van Petten
中科院分区：
文献类型：
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作者：
Q. Pittman;K. Cooper;W. Veale;G. V. van Petten
1.新生羔羊静脉注射细菌热原的初始注射未能引起发热，但确实导致循环血液白细胞数量下降。2.第二次挑战的细菌热原在60小时的老羔羊引起发烧，而其他60小时的老羔羊，以前没有注射热原，没有反应。3.因此，新生羔羊需要通过暴露于内毒素致敏，才能发生热原诱导的发热。4.当将细菌热原静脉注射到子宫内未麻醉的胎仔中时，胎仔和母体体温对初始激发和随后在子宫内或出生后立即在羔羊中注射一次或两次细菌热原的反应保持不变。在所有情况下，注射后90 min内胎仔白色细胞计数均下降。5.对细菌热原和白细胞热原的反应似乎取决于热原热中涉及的生理机制的成熟度。
1. An initial injection of intravenous bacterial pyrogen in newborn lambs failed to produce fever, but did cause a fall in the number of circulating blood leucocytes. 2. A second challenge of bacterial pyrogen in 60-h-old lambs caused fever, whereas other 60-h-old lambs, not previously injected with pyrogen, were unresponsive. 3. Thus the newborn lamb requires sensitization, by exposure to endotoxin, before pyrogen-induced fever can occur. 4. When bacterial pyrogen was injected intravenously into the unanaesthetized foetus in utero , foetal and maternal body temperatures remained unchanged in response to the initial challenge and to one or two subsequent injections of bacterial pyrogen in utero , or in the lamb immediately after birth. In all instances the foetal white cell count fell in the 90 min after the injection. 5. The response to both bacterial pyrogen and leucocyte pyrogen appears to depend upon the maturity of the physiological mechanisms involved in pyrogen fever.